TCDB is operated by the Saier Lab Bioinformatics Group

1.D.53 The alpha,gamma-Peptide Nanotube (a,gPepNT) Family 

One advantage of peptide nanotubes composed of gamma-amino acids is that the properties of their inner cavities can be tuned by introducing different functions on beta-carbon of the gamma-amino acid. The presence of different numbers of hydroxyl groups in different positions in the lumen of these channels when they are inserted into a lipid bilaye determine the ion transport properties of the channel.  They affect the structural and dynamic behavior of the modified peptide nanotubes as well as the transmembrane transport of different ions (Calvelo et al. 2015).

References associated with 1.D.53 family:

Calvelo, M., S. Vázquez, and R. García-Fandiño. (2015). Molecular dynamics simulations for designing biomimetic pores based on internally functionalized self-assembling α,γ-peptide nanotubes. Phys Chem Chem Phys 17: 28586-28601. 26443433