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1.D.54 The potassium-selective Hexyl-Benzoureido-15-Crown-5-Ether Channel (HBEC) Family

Artificial ion-channels of H-bonded hexyl-benzoureido-15-crown-5-ether are selective for K+ over Na+. K+-channel conductance arises from the formation of oligomeric cooperative channels, resulting in cation-induced membrane polarization and enhanced transport rates. These channels are selectively responsive to the presence of K+ cations, even in the presence of a large excess of Na+ (Gilles and Barboiu 2015).


References associated with 1.D.54 family:

Gilles, A. and M. Barboiu. (2015). Highly selective artificial K+-channels: an example of selectivity in-duced transmembrane potential. J. Am. Chem. Soc. [Epub: Ahead of Print] 26692073