1.D.82. The Electroporation-genetrated Pore (EgP) Family
The applications of nanosecond, megavolt-per-meter electric field pulses to biological systems show cellular and subcellular electric field induced effects of electroporation. The absolute rate theory, with experimentally based parameter input, is consistent with membrane pore creation on a nanosecond time scale. Use of a Smoluchowski equation-based model for a planar cell membrane patch exposed to a 10 ns trapezoidal pulse with 1.5 ns rise and fall times, reversible supraelectroporation behavior in terms of transmembrane voltage, pore density, membrane conductance, fractional aqueous area, pore distribution, and average pore radius has been determined (Vasilkoski et al. 2006). Pore creation dominates the electrical response, and pore expansion prived to be negligible on this ns time scale.