TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.E.19.1.1









Holin (161 aas)

Bacteria
Actinobacteria
Holin of Mobiluncus mulieris
*1.E.19.1.2









Uncharacterized protein

Bacteria
Firmicutes
Uncharacterized protein of Lachnospiraceae bacterium
*1.E.19.1.3









Putative holin of 152 aas and 3 TMSs

Bacteria
Firmicutes
Putative holin of Brevibacillus brevis
*1.E.19.1.4









Uncharacterized protein

Viruses
Caudovirales
Uncharacterized protein of Bacillus phage IEBH
*1.E.19.1.5









Uncharacterized protein (142 aas)

Bacteria
Firmicutes
Uncharacterized protein of Clostridium bolteae
*1.E.19.1.6









Holin

Bacteria
Actinobacteria
Holin of Corynebacterium diphtheriae
*1.E.19.1.7









Putative holin of 139 aas nd 3 TMSs

Bacteria
Thermotogae
Putative holin of Petrotoga mobilis
*1.E.19.1.8









Prophage lambda Sa04 protein

Bacteria
Firmicutes
Sa04 protein of Megasphaera elsdenii
*1.E.19.1.9









Holin (129 aas)

Bacteria
Fusobacteria
Fusobacterium sp. ZP-0
*1.E.19.1.10









Phage-related holin of 142 aas and 4 TMSs

Bacteria
Tenericutes
Holin of Acholeplasma laidlawii
*1.E.19.1.11









Holin of 141 aas and 2 TMSs

Bacteria
Chloroflexi
Holin of Dehalococcoides ethenogenes
*1.E.19.1.12









Holin of 137 aas and 2 TMSs (Jin et al. 2013).

Viruses
Caudovirales
Holin of Geobacillus phage GBSV1
*1.E.19.1.13









Toxin secretion/holin system; holin of 124 aas

Bacteria
Tenericutes
Holin of Mycoplasma sp.
*1.E.19.1.14









Putative holin of 142 aas

Bacteria
Chloroflexi
Putative holin of Herpetosiphon aurantiacus
*1.E.19.1.15









Putative holin of 141 aas and 3 TMSs

Bacteria
Bacteroidetes/Chlorobi group
Putative holin of Alistipes shahii
*1.E.19.1.16









Holin of 138 aas and 3 TMSs (Kong and Ryu 2015).

Viruses
Caudovirales
Holin of Bacillus phage PBC1
*1.E.19.2.1









Holin of 170 aas and 3 TMSs

Bacteria
Firmicutes
Holin of Macrococcus caseolyticus
*1.E.19.2.2









Staphylococcus aureus phage P68 holin, hol15 (Takác et al. 2005).

Viruses
Caudovirales
Hol15 of Staphylococcal phage P68
*1.E.19.2.3









phage-like holin, YqxH1 (135 aas)

Bacteria
Firmicutes
YqxH1 of Bacillus amyloliquefaciens
*1.E.19.3.1









The C. difficile holin, TcdE.  TcdE acts as a holin-like protein to facilitate the release of C. difficile toxins A and B to the extracellular environment, but, unlike most phage holins, it does not cause the non-specific release of cytosolic contents. TcdE is thus a bacterial holin that releases toxins into the environment by a phage-like system (Tan et al. 2001; Govind and Dupuy 2012).  Different isoforms have differing activities in toxin release (Govind et al. 2015).

Bacteria
Firmicutes
TcdE of Clostridium difficile
*1.E.19.3.2









Holin of 141 aas and 3 TMSs, TcsE (Sirigi Reddy et al. 2013).

Bacteria
Firmicutes
TcsE of Clostridium sordellii
*1.E.19.4.1









Holin of Clostridium phage phi3626.  The function has been demonstrated (Zimmer et al. 2002).  The charge distribution of this 2 TMS protein suggestions that the β-turn between TMSs 1 and 2, with 7 lys and arg residues, is in the cytoplasm and the N- and C-termini are in the periplasm (Zimmer et al. 2002).

Viruses
Caudovirales
Holin of Clostridium phage phi3626
*1.E.19.4.2









Toxin secretion holin of 137 aas and 3 TMSs.

Bacteria
Actinobacteria
Holin of Atopobium minutum
*1.E.19.4.3









Putative holin of 158 aas and 3 TMSs.

Bacteria
Actinobacteria
Putative holin of Gardnerella vaginalis
*1.E.19.5.1









Holin of 162 aas and 3 TMSs

Bacteria
Proteobacteria
Putative holin of Desulfovibrio vulgaris
*1.E.19.6.1









Putative holin of 178 aas and 4 TMSs

Bacteria
Bacteroidetes/Chlorobi group
Holin of Pedobacter saltans
*1.E.19.6.2









Putative holin of 181 aas and 3 TMSs

Bacteria
Bacteroidetes/Chlorobi group
Holin of Capnocytophaga sputigena
*1.E.19.6.3









Putative holin of 170 aas and 3 TMSs

Bacteria
Bacteroidetes/Chlorobi group
Holin of Cyclobacterium marinum (Flectobacillus marinus)