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1.E.29  The Holin Hol44 (Hol44) Family

Oenococcus oeni cells are intrinsically resistant to the secreted endolysin from oenophage fOg44 (Lys44). Experiments with several antimicrobials support the hypothesis that the full activity of Lys44 requires sudden ion-nonspecific dissipation of the proton motive force, an event undertaken by the fOg44 holin in the phage infection context (Nascimento et al. 2008).

This family belongs to the: Holin Superfamily V.

References associated with 1.E.29 family:

Goh, S., P.F. Ong, K.P. Song, T.V. Riley, and B.J. Chang. (2007). The complete genome sequence of Clostridium difficile phage phiC2 and comparisons to phiCD119 and inducible prophages of CD630. Microbiology 153: 676-685. 17322187
Nascimento, J.G., M.C. Guerreiro-Pereira, S.F. Costa, C. São-José, and M.A. Santos. (2008). Nisin-triggered activity of Lys44, the secreted endolysin from Oenococcus oeni phage fOg44. J. Bacteriol. 190: 457-461. 17981964
Oki, M., M. Kakikawa, S. Nakamura, E.T. Yamamura, K. Watanabe, M. Sasamoto, A. Taketo, and K. Kodaira. (1997). Functional and structural features of the holin HOL protein of the Lactobacillus plantarum phage phi gle: analysis in Escherichia coli system. Gene 197: 137-145. 9332359