TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.E.4.1.1









LydA protein
Bacteria
Proteobacteria
LydA protein (109 aas; pirS18681)
*1.E.4.1.2









LydC of enterobacterial phage P1

Viruses
Caudovirales
LydC of phage P1
*1.E.4.1.3









Hypothetical protein (113 aas)

Bacteria
Proteobacteria
Hypothetical protein of Burkholderia phytofirmans
*1.E.4.1.4









Holin of 134 aas and 4 TMSs.  The lysis genes encode the holin, peptidase M15A or endolysin, lysB and lysC. Each gene and combinations were cloned into Escherichia coli and the lytic effects were measured. Co-expression of holin and peptidase M15A showed the highest lysis activity. Expression of holin, lysB/C or holin, peptidase M15A, lysB and lysC lysed the E. coli membrane whereas peptidase M15A alone did not. The predicted transmembrane structures of holin and lysB/C indicated they could insert into the bacterial membrane to form pores, affecting cell permeability and causing lysis (Khakhum et al. 2016).

Viruses
Caudovirales
Holin of Burkholderia phage ST79