TCDB is operated by the Saier Lab Bioinformatics Group

1.G.18 The SARS-CoV Fusion Peptide in the Spike Glycoprotein Precursor (SARS-FP) Family

The severe acute respiratory syndrom (SARS) coronavirus (CoV) fusion peptide in the spike glycoprotein precursor (SARS-FP) Family.  The fusion peptide is an N-terminal 19 aas peptide, in the spike glycoprotein precursor of 1255 aas.  The fusion peptide is 19 aas in length (Apellániz et al. 2014). Members of this family has a central CDD/Pfam Spike_rec_bind domain and a large C-terminal Corona_S2 domain.

References associated with 1.G.18 family:

Apellaniz B., Huarte N., Largo E. and Nieva JL. (2014). The three lives of viral fusion peptides. Chem Phys Lipids. 181:40-55. 24704587
Liao, Y., Q. Yuan, J. Torres, J.P. Tam, and D.X. Liu. (2006). Biochemical and functional characterization of the membrane association and membrane permeabilizing activity of the severe acute respiratory syndrome coronavirus envelope protein. Virology 349: 264-275. 16507314
Petit, C.M., V.N. Chouljenko, A. Iyer, R. Colgrove, M. Farzan, D.M. Knipe, and K.G. Kousoulas. (2007). Palmitoylation of the cysteine-rich endodomain of the SARS-coronavirus spike glycoprotein is important for spike-mediated cell fusion. Virology 360: 264-274. 17134730