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1.G.18 The SARS-CoV Fusion Peptide in the Spike Glycoprotein Precursor (SARS-FP) Family

The severe acute respiratory syndrom (SARS) coronavirus (CoV) fusion peptide in the spike glycoprotein precursor (SARS-FP) Family.  The fusion peptide is an N-terminal 19 aas peptide, in the spike glycoprotein precursor of 1255 aas.  The fusion peptide is 19 aas in length (Apellániz et al. 2014). Members of this family has a central CDD/Pfam Spike_rec_bind domain and a large C-terminal Corona_S2 domain.

References associated with 1.G.18 family:

Apellaniz B., Huarte N., Largo E. and Nieva JL. (2014). The three lives of viral fusion peptides. Chem Phys Lipids. 181:40-55. 24704587
Petit, C.M., V.N. Chouljenko, A. Iyer, R. Colgrove, M. Farzan, D.M. Knipe, and K.G. Kousoulas. (2007). Palmitoylation of the cysteine-rich endodomain of the SARS-coronavirus spike glycoprotein is important for spike-mediated cell fusion. Virology 360: 264-274. 17134730