1.N.2 The Myoblast Fusion Complex (MFC) Family
Existing evidence suggests that several proteins may be involved in myoblast fusion is various systems (Schejter 2016). The principal protein constituents that could mediate myoblast pore-formatioin and fusion are (1) annexins A1 and A5, Ca2+-regulated phospholipid binding proteins (TC# 1.A.31.1.3 and, 1.7, respectively), Singles-bar (Sing) with a MARVEL domain (TC# 9.A.69.1.1), present in Drosophila, and human Myomaker, a transmembrane (7 TMS) myoblast fusogen, also known as Tmem8c, that increases fusion rates in humans, fruit flies, chickens and zebrafish (Schejter 2016). Myomaker may mediate fusioin of several types of cells in additioin to myoblasts. In C. elegans, there are proteins called FF fusogens (TC#9.A.68.1.1) that may mediate cell fusion. Other proteins that can mediate fusion in humans are the Syncytins (TC# 1.G.9.1.1).