TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.N.4.1.1









EFF-1A of 658 aas and 2 TMSs, N- and C-terminal.  Required for normal cell fusion. The EFF-1A endodomain is required for normal rates of EFF-1-dependent epidermal cell fusions (Shinn-Thomas et al. 2016).

Eukaryota
Metazoa
EFF1A of Caenorhabditis elegans
*1.N.4.1.2









EFF-1B of 596 aas and 2 TMSs, N- and C-terminal (Kontani and Rothman 2005).

Eukaryota
Metazoa
EFF-1B of Caenorhabditis elegans
*1.N.4.1.3









Myoblast syncytium formation protein generated by plasma membrane fusion of 852 aas and 4 - 5 TMSs.  The roles of the major signaling pathways in mammalian myoblast fusion have been reviewed (Hindi et al. 2013).

 

Eukaryota
Metazoa
FFF protein of Branchiostoma floridae (Florida lancelet) (Amphioxus)
*1.N.4.1.4









Cell fusion protein, AFF-1 of 589 aas and 2 TMSs, one N-terminial and one C-terminal (Soulavie and Sundaram 2016).  Required for cell fusion events during development including the fusion of anchor cells (AC), vulval A and vulval D rings, and late epidermal seam cells (Sapir et al. 2007). In response to environmental stressors, C. elegans enters a diapause state, termed dauer, which is accompanied by remodeling of sensory neuron receptive endings, dependent on AFF-1 (Sapir et al. 2007). In response to environmental stressors, C. elegans enters a diapause state, termed dauer, which is accompanied by remodeling of sensory neuron receptive endings, dependent on AFF-1 (Procko et al. 2011).

Eukaryota
Metazoa
AFF-1 of Caenorhabditis elegans
*1.N.4.1.5









Uncharacterized fusogen protein of 567 aas and 2 TMSs.

Eukaryota
Metazoa
Putative fusogen of Trichinella spiralis (Trichina worm)