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1.N.4.1.4
Cell fusion protein, AFF-1 of 589 aas and 2 TMSs, one N-terminial and one C-terminal (Soulavie and Sundaram 2016).  Required for cell fusion events during development including the fusion of anchor cells (AC), vulval A and vulval D rings, and late epidermal seam cells (Sapir et al. 2007). In response to environmental stressors, C. elegans enters a diapause state, termed dauer, which is accompanied by remodeling of sensory neuron receptive endings, dependent on AFF-1 (Sapir et al. 2007). In response to environmental stressors, C. elegans enters a diapause state, termed dauer, which is accompanied by remodeling of sensory neuron receptive endings, dependent on AFF-1 (Procko et al. 2011).

Accession Number:G5EGL9
Protein Name:Cell fusion protein aff-1
Length:589
Molecular Weight:67463.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell membrane1 / Single-pass type I membrane protein2
Substrate small molecules, macromolecules

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FASTA formatted sequence
1:	MRLWQWSIAV AICLVMVTEA RLRRHHRKRR FVSSNFDEFY CGESAHAQSQ FEEERESNSS 
61:	KVSSVHSTQF NWGLDNTICI KLQNVVHVLK YERLEQRYPI ENSYTFSVPL IDTNCKCHCY 
121:	GFGTNDVCNV EKYADDRNCT TSSEFPTCYT KYHPAVEPLD CPVTSIPAKA CCDIKLKPRD 
181:	GRMFRAVKLQ QPINDMIISH SIFANNSGKM MKVLGPDEFR INLLKGKEQF ELTEYHRISV 
241:	QLVASSPQQQ LREGMYYFPE ENHNDLREGK INEITESDLD KLGWYRRVGN DWQVATSGLL 
301:	LRNAHKVVIK NCKGQVHMDQ FSGTKNFVLR GTQYNDTYNE RRVSDNNFVR SVKVDESSRE 
361:	ITIVHEHGTA AQVSLKTDTR PNLTKSQSLL ANFTGSITLD HDGNRMLNVT FFGVKGTVHI 
421:	KMYVNDRKLI ATFACTAQFG TSLKDDGSRI SLPSTINQAQ WVCILPDEQP TKSEICKWIP 
481:	YEEKAMRTPR QEQSWSKGHS PCSQAECNSL KSGVSDLFPW IMNFDYFMAH GGDFTEWLKI 
541:	GIHIVIAVGL LLLLILLFTK CLVPLACCSL SIPFKNRNKK KKKKNSSDY