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2.A.1.19.16
The organic anion transporter, Oat6 or SLC22a20 of 556 aas and 12 TMSs.  Binding and transport rates for 40 anionic substrates have been studied and compared with those for Oat1 (TC# 1.A.1.19.4) (Kaler et al., 2007). Oat6 transports many antiviral agents (Truong et al., 2008). It can bind odorants and is present in the mouse olfactory mucosa; it has been proposed to be an odorant receptor and/or odorant transporter (Wu et al. 2015).

Accession Number:Q80UJ1
Protein Name:Organic anion transporter 6 aka Oat6
Length:556
Molecular Weight:60944.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Organic anions, Antivirals

Cross database links:

Genevestigator: Q80UJ1
eggNOG: roNOG12130
HEGENOM: HBG713776
RefSeq: NP_941052.1   
Entrez Gene ID: 381203   
Pfam: PF00083   
KEGG: mmu:381203   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0008514 F:organic anion transmembrane transporter act...
GO:0015711 P:organic anion transport

References (6)

[1] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[2] “Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa.”  Monte J.C.et.al.   15369770
[3] “Transport of estrone sulfate by the novel organic anion transporter Oat6 (Slc22a20).”  Schnabolk G.W.et.al.   16478971
[4] “Olfactory mucosa-expressed organic anion transporter, Oat6, manifests high affinity interactions with odorant organic anions.”  Kaler G.et.al.   17094945
[5] “Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members.”  Kaler G.et.al.   17553798
[6] “Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination.”  Truong D.M.et.al.   18174163

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAFTDLLDAL GGVGRFQLVY TALLLLPCGL LACHTFLQNF TAAAPPHHCQ HPANYTEPTT 
61:	NVSGVWLRAA IPLNQHGDPE PCRRYVEPQW ALLKPNASSH GVATEGCKDG WVYDRSIFPS 
121:	TIVMEWDLVC EARTLRDLAQ SIYMSGVLVG AALFGGLADR LGRKAPLVWS YLQLAVSGAA 
181:	TAYVGSFSAY CVFRFLMGMT FSGIILNSLS LVVEWMPTRG RTVAGILLGF SFTLGQLILA 
241:	GVAYLIRPWR WLQFAVSAPF LVFFLYSWWL PESSRWLLLH GKAQQAVQNL QKVAMMNGRK 
301:	AEGERLTTEV VSSYIQDEFA SVRTSNSILD LFRTPAIRRV TCCLMGVWFS NSVAYYGLAM 
361:	DLQKFGLSIY LVQALFGIID IPAMLVATTT MIYVGRRATV SSFLILAGLM VIANMFMPED 
421:	LQTLRTVQAA LGKGCLASSF ICVYLFTGEL YPTEIRQMGM GFASVNARLG GLVAPLITTL 
481:	GEISPVLPPV SFGATSVLAG MAVACFLTET RNVPLVETIA AMERRVKQGR SKRDTEQKSE 
541:	EISLQQLGAS PLKETI