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2.A.1.2.111
Zinc-induced facilitator-like protein 1, ZIFL1 or Tpo1p  of 478 aas and 12 TMSs. It confers resistance to the herbicide, 2,4-dichlorophenoxyacetic acid (2,4-D) and is transcriptionally activated in response to this herbicide. Tpo1p is required to reduce the intracellular concentration of 2,4-D (Cabrito et al. 2009). K+ may be its physiological substrate, and it may play a dual role in polar auxin transport and drought stress tolerance (Remy et al. 2013). It is also involved in auxin efflux and acts as a positive regulator of shootward transport at the root apex. Possibly, it may mediate proton efflux from the vacuolar compartment (Remy et al. 2013).

Accession Number:Q94BZ1
Protein Name:Protein ZINC INDUCED FACILITATOR-LIKE 1
Length:478
Molecular Weight:52299.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell membrane1
Substrate

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FASTA formatted sequence
1:	MAEEYAECLL EKNFHEDCSG CKVDQMKRLR RGFPFWELFT VWIIVLCTAL PISSLFPFLY 
61:	FMIDDFNIAK KEEDIGFYAG FVGCSFMLGR AFTSVAWGLV ADRYGRKPVI LIGTASVVVF 
121:	NTLFGLSLNF WMAIITRFCL GSFNGLLGPI KAYAMEIFRD EYQGLALSAV STAWGIGLII 
181:	GPAIGGFLAQ PAKQYPSLFS QDSIFGKFPF FLPCLAISVF AFLVTIVSSR IPETLHNHKF 
241:	NDDESYDALK DLSDDPESNK VAERNGKSSL LNNWPLISSI IVYCVFSLHD MAYTEIFSLW 
301:	ANSPRKYGGL GYSTADVGSV LAFSGFGLLI FQLSLYSYAE RLLGPIIVTR ISGSLAMVVL 
361:	SCYPLIAKLS GLALTVTVTS ASVAKSVLGT SAITGLFILQ NKAVRQDQRG AANGIAMTAM 
421:	SLFKAIGPAA AGIIFSWSEK RQGAAFLPGT QMVFFILNVV LALGVVLTFK PFLAETQQ