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2.A.10 The 2-Keto-3-Deoxygluconate Transporter (KdgT) Family

The KdgT permease of Erwinia chrysanthemi is the only well-characterized member of the KdgT family although homologues are present in many bacteria.  Thus, members of the family are present both in Gram-negative and Gram-positive bacteria (Allen et al. 1989). The protein from E. chrysanthemi possesses 398 amino acids and probably traverses the membrane as α-helicies 10-12 times. Uptake is energized by proton symport (Condemine and Robert-Baudouy 1987).

The transport reaction catalyzed by KdgT is:

KDG (out) + H+ (out)  KDG (in) + H+ (in).


 

 

 

This family belongs to the: BART Superfamily.

References associated with 2.A.10 family:

Allen, C., S. Reverchon, and J. Robert-Baudouy. (1989). Nucleotide sequence of the Erwinia chrysanthemi gene encoding 2-keto-3-deoxygluconate permease. Gene 83: 233-241. 2684787
Condemine, G. and J. Robert-Baudouy. (1987). 2-keto-3-deoxygluconate transport system in Erwinia chrysanthemi. J. Bacteriol. 169: 1972-1978. 3571157
Luoto, H.H., E. Nordbo, A.M. Malinen, A.A. Baykov, and R. Lahti. (2015). Evolutionarily divergent, Na+-regulated H+-transporting membrane-bound pyrophosphatases. Biochem. J. 467: 281-291. 25662511
Pujic, P., R. Dervyn, A. Sorokin, and S.D. Ehrlich. (1998). The kdgRKAT operon of Bacillus subtilis: detection of the transcript and regulation by the kdgR and ccpA genes. Microbiology 144(Pt11): 3111-3118. 9846747