TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*2.A.100.1.1









The iron exporter Ferroportin1 (Fnp1 or IREG1)

Eukaryota
Metazoa
Ferroportin (IREG1) of Mus musculus
*2.A.100.1.2









The probable chloroplast Fe transporter, Mar1 (Conte et al., 2009)

Eukaryota
Viridiplantae
Mar1 of Arabidopsis thaliana (Q8W4E7)
*2.A.100.1.3









Ferroportin1 or Iron-regulated protein1, 9FPN1, IREG1, ATIREG1; exports Fe2+, Co2+ and Ni2+ (Morrissey et al., 2009)

Eukaryota
Viridiplantae
FPN1 of Arabidopsis thaliana (O80905)
*2.A.100.1.4









Solute carrier family 40 member 1 (Ferroportin-1; FPN1) (Iron-regulated transporter 1).  Transports iron, cobalt, zinc and manganese and maybe copper (Madejczyk and Ballatori 2012).  Regulated by its inhibitor, the processed liver antimicrobial peptide, hepcidin (TC# 8.A.37.1.2).  Tryptophan 42, a hemochromatosis type 4 disease residue, plays a role in iron export and iron homeostasis as well as hepcidin binding (Le Gac et al. 2013).  This protein has been modeled using the MSF EmrD of E. coli (TC# 2.A.1.2.9) (Le Gac et al. 2013). Defects can be corrected by adding the small molecule, hinokitiol (Cioffi et al. 2015; Grillo et al. 2017). The R178Q mutation is a recurrent cause of hemochromatosis and is associated with a novel pathogenic mechanism (Ka et al. 2018).

Eukaryota
Metazoa
FPN1 or SLC40A1 of Homo sapiens
*2.A.100.1.5









Ferroportin of 565 aas and 12 TMSs.

Eukaryota
Viridiplantae
Fpn of Chlorella variabilis (Green alga)
*2.A.100.1.6









Uncharacterized ferroportin homolog of 560 aas and 14 TMSs, with two extra TMSs between the two 6 TMS repeat units.

Eukaryota
Oomycetes
UP of Peronospora effusa
*2.A.100.2.1









Ferroportin of 440 aas and 12 TMSs. Transports Fe2+, Co2+, Mn2+ and Ni2+. The 3-d structures in both the inward and outward facing orientations have been determined, showing similarities to those of MFS permeases (Taniguchi et al. 2015). This protein shows an alignment of almost the entire protein with MFS protein, 2.A.1.62.4 with a BLAST score of e-12, strongly indicative of homology.

Bacteria
Proteobacteria
Ferroportin of Bdellovibrio bacteriovorus
*2.A.100.2.2









Uncharacterized Ferroporin homologue of 592 aas and 12 putative TMSs.

Eukaryota
Acytosteliales
UP of Acytostelium subglobosum