TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*2.A.100.1.1









The iron exporter Ferroportin1 (Fnp1 or IREG1)

Eukaryota
Metazoa
Ferroportin (IREG1) of Mus musculus
*2.A.100.1.2









The probable chloroplast Fe transporter, Mar1 (Conte et al., 2009)

Eukaryota
Viridiplantae
Mar1 of Arabidopsis thaliana (Q8W4E7)
*2.A.100.1.3









Ferroportin1 or Iron-regulated protein1, 9FPN1, IREG1, ATIREG1; exports Fe2+, Co2+ and Ni2+ (Morrissey et al., 2009)

Eukaryota
Viridiplantae
FPN1 of Arabidopsis thaliana (O80905)
*2.A.100.1.4









Solute carrier family 40 member 1 (Ferroportin-1; FPN1) (Iron-regulated transporter 1).  Transports iron, cobalt, zinc and manganese and maybe copper (Madejczyk and Ballatori 2012).  Regulated by its inhibitor, the processed liver antimicrobial peptide, hepcidin (TC# 8.A.37.1.2).  Tryptophan 42, a hemochromatosis type 4 disease residue, plays a role in iron export and iron homeostasis as well as hepcidin binding (Le Gac et al. 2013).  This protein has been modeled using the MSF EmrD of E. coli (TC# 2.A.1.2.9) (Le Gac et al. 2013). Defects can be corrected by adding the small molecule, hinokitiol (Cioffi et al. 2015; Grillo et al. 2017). The R178Q mutation is a recurrent cause of hemochromatosis and is associated with a novel pathogenic mechanism (Ka et al. 2018).

Eukaryota
Metazoa
FPN1 or SLC40A1 of Homo sapiens
*2.A.100.1.5









Ferroportin of 565 aas and 12 TMSs.

Eukaryota
Viridiplantae
Fpn of Chlorella variabilis (Green alga)
*2.A.100.1.6









Uncharacterized ferroportin homolog of 560 aas and 14 TMSs, with two extra TMSs between the two 6 TMS repeat units.

Eukaryota
Oomycetes
UP of Peronospora effusa
*2.A.100.1.7









Ferroportin (Fpn) of 562 aas and 12 TMSs (Rafiee et al. 2012).

Eukaryota
Metazoa
Fpn of Danio rerio (zebrafish)
*2.A.100.2.1









Ferroportin of 440 aas and 12 TMSs. Transports Fe2+, Co2+, Mn2+ and Ni2+. The 3-d structures in both the inward and outward facing orientations have been determined, showing similarities to those of MFS permeases (Taniguchi et al. 2015). The Fpn family is a member of the MFS. Fpn-mediated iron efflux is stimulated by extracellular Ca2+ in the physiological range, even though  Ca2+ is not transported. Deshpande et al. 2018 determined the crystal structure of Ca2+-bound BbFpn (TC# 2.A.100.2.1), and found that Ca2+ is a cofactor that facilitates a conformational change critical to the transport cycle. They also identified a substrate pocket accommodating a divalent transition metal complexed with a chelator. These findings support a model of iron export by Fpn and suggest a link between plasma calcium and iron homeostasis (Deshpande et al. 2018).

Bacteria
Proteobacteria
Ferroportin of Bdellovibrio bacteriovorus
*2.A.100.2.2









Uncharacterized Ferroporin homologue of 592 aas and 12 putative TMSs.

Eukaryota
Acytosteliales
UP of Acytostelium subglobosum