TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*2.A.100.1.1









The iron exporter Ferroportin1 (Fnp1 or IREG1)

Eukaryota
Metazoa
Ferroportin (IREG1) of Mus musculus
*2.A.100.1.2









The probable chloroplast Fe transporter, Mar1 (Conte et al., 2009)

Eukaryota
Viridiplantae
Mar1 of Arabidopsis thaliana (Q8W4E7)
*2.A.100.1.3









Ferroportin1 or Iron-regulated protein1, 9FPN1, IREG1, ATIREG1; exports Fe2+, Co2+ and Ni2+ (Morrissey et al., 2009)

Eukaryota
Viridiplantae
FPN1 of Arabidopsis thaliana (O80905)
*2.A.100.1.4









Solute carrier family 40 member 1 (Ferroportin-1; FPN1) (Iron-regulated transporter 1).  Transports iron, cobalt, zinc and manganese and maybe copper (Madejczyk and Ballatori 2012).  Regulated by its inhibitor, the processed liver antimicrobial peptide, hepcidin (TC# 8.A.37.1.2).  Tryptophan 42, a hemochromatosis type 4 disease residue, plays a role in iron export and iron homeostasis as well as hepcidin binding (Le Gac et al. 2013).  This protein has been modeled using the MSF EmrD of E. coli (TC# 2.A.1.2.9) (Le Gac et al. 2013). Defects can be corrected by adding the small molecule, hinokitiol (Cioffi et al. 2015; Grillo et al. 2017).

Eukaryota
Metazoa
FPN1 or SLC40A1 of Homo sapiens
*2.A.100.1.5









Ferroportin of 565 aas and 12 TMSs.

Eukaryota
Viridiplantae
*2.A.100.2.1









Ferroportin of 440 aas and 12 TMSs. Transports Fe2+, Co2+, Mn2+ and Ni2+. The 3-d structures in both the inward and outward facing orientations have been determined, showing similarities to those of MFS permeases (Taniguchi et al. 2015).

Bacteria
Proteobacteria
Ferroportin of Bdellovibrio bacteriovorus