2.A.114 The Peptide Transporter Carbon Starvation CstA (CstA) Family
The CstA family consists of proteins from bacteria, and archaea. These proteins are of various sizes and topologies. For example, CstA of E. coli has 701 aas with 18 putative TMSs. It has a long N-terminal CstA domain and a short C-terminal DUF4161 domain. This protein is encoded by a carbon starvation inducible gene cstA that is under cyclic AMP-CRP control. Circumstantial evidence suggested that it may be a peptide transporter (Schultz and Matin, 1991). A Campylobacter jejuni homologue has been shown to transport di- and tripeptides (see TC# 2.A.114.1.5) (Rasmussen et al., 2013).