TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
2.A.117.1:  The (mainly) Proteobacterial Chlorhexidine Efflux (PCE) family
*2.A.117.1.1









The Chlorhexidine drug-resistance exporter, AceI of 179 aas and 4 TMSs (Hassan et al. 2013) .  It is capable of exporting multiple drugs such as benzalkonium, dequalinium, proflavine, and acriflavine. (Hassan et al. 2015).

Bacteria
Proteobacteria
AceI of Acinetobacter baumannii
*2.A.117.1.2









Chlorhexidine-responsive chlorhexadine exporter of 171 aas and 4 TMSs.

Bacteria
Proteobacteria
AceI of Pseudomonas aeruginosa
*2.A.117.1.3









Chlorhexidine-responsive putative chlorhxidine exporter of 160 aas and 4 TMSs, AceI.

Bacteria
Proteobacteria
AceI of Salmonella typhi
*2.A.117.1.4









Chlorhexidine-unresponsive putative drug exporter of 147 aas and 4 TMSs.

Bacteria
Proteobacteria
Drug exporter of Pseudomonas aeruginosa
*2.A.117.1.5









Chlorhexidine-unresponsive putative drug exporter of 144 aas and 4 TMSs.

Bacteria
Proteobacteria
Drug exporter of Desulfovibrio vulgaris
*2.A.117.1.6









Uncharacterized putative drug exporter of 134 aas and 4 TMSs.

Bacteria
Firmicutes
UP of Veillonella parvula
*2.A.117.1.7









Uncharacterized putative drug exporter of 147 aas and 4 TMSs.

Bacteria
Proteobacteria
UP of Methylobacterium populi
*2.A.117.1.8









Uncharacterized putative drug exporter of 179 aas and 4 TMSs.

Bacteria
Actinobacteria
UP of Micrococcus luteus
*2.A.117.1.9









Uncharacterized putative drug exporter of 346 aas and 4 N-terminal TMSs with a long C-terminal hydrophilic domain.

Bacteria
Proteobacteria
UP of Pseudomonas fluorescens
*2.A.117.1.10









Uncharacterized putative drug exporter of 148 aas and 4 TMSs.

Bacteria
Proteobacteria
Transmembrane poir domain-protein of Azospira oryzae (Dechlorosoma suillum)
*2.A.117.1.11









Uncharacterized putative drug exporter of 140 aas and 4 TMSs.

Bacteria
Proteobacteria
UP of Shewanella hoihica
*2.A.117.1.12









The Unknown Bacterial Transmembrane Pair (UBTP) family member of 146 aas and 4 TMSs.  Chlorhexidine-unresponsive (Hassan et al. 2013).

Bacteria
Proteobacteria
UBTP family member of Burkholderia cenocepacia
*2.A.117.1.13









Member of the Proteobacterial Antimicrobial Compound Efflux (PACE) family.  This protein is of 140 aas with 4 TMSs.  It has been shown to be an active drug exporter, conferring resistance to both proflavine and acriflavine, mediated by an active efflux mechanism (Hassan et al. 2018).

Bacteria
Proteobacteria
UBTP2 family member of Vibrio parahaemolyticus
*2.A.117.2.1









Uncharacterized putative drug exporter of 142 aas and 4 TMSs.

Bacteria
Proteobacteria
UP of Rhodobacter spheroides