TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*2.A.122.1.1









LrgB (YohK) protein (putative murein hydrolase export regulator; LrgA-associated protein) (7 probable TMSs based on topological analyses. This protein and 2.A.122.1.2 with 8 TMSs appear to derive from a 4 TMS precursor that duplicated to give 8, and LrgB may have lost TMS 1.  It does not appear to be a member of the TOG superfamily.). LrgB decreases antibiotic sensitivity (Yang et al., 2005).

Bacteria
Proteobacteria
LrgB of E. coli (C6EAH0)
*2.A.122.1.2









Putative holin-mediated export regulatory protein, CidB (8 TMSs with an internal repeat of 4 TMSs). It enhances antibiotic sensitivity (Yang et al., 2005). CidA is a holin-like protein (TC# 1.E.14.1.2). The cidABC operon is controlled by CidR, an activator in the presence of acetic acid (Yang et al., 2005).

Bacteria
Firmicutes
CidB of Staphylococcus aureus (H4HJS5)
*2.A.122.1.3









Putative antiholin-like protein of 233 aas and 8 TMSs, LrgB (Chu et al. 2013).  Proposed to function together with LrgA as a holin/antiholin pair to export autolysins, LytM and LytN. However, the identification of a larger fused plant homologue (9.B.117.1.4) as a plastidic glycolate glycerate transporter (Pick et al. 2013) sheds doubt on this proposal.

Bacteria
Firmicutes
LrgB of Staphylococcus aureus
*2.A.122.1.4









Bacteria
Firmicutes
*2.A.122.1.5









Putative antiholin of 225 aas and 6 TMSs, LrgB or YwbG (Chen et al. 2015). Inhibits the activity of putative holin, CidA or YwbH (TC# 1.E.14.1.16).

Bacteria
Firmicutes
YwbG of Bacillus subtilis
*2.A.122.1.6









Putative antiholin of 231 aas and 8 TMSs, YsbB or LrgB (Chen et al. 2015).  Believed to counteract the holin activity of YsbA (TC# 1.E.14.1.17).

Bacteria
Firmicutes
YsbB of Bacillus subtilis
*2.A.122.1.7









Putative anit-holin, YxaC of 230 aas and 6-8 TMSs (Chen et al. 2015).

Bacteria
Firmicutes
YxaC of Bacillus subtilis
*2.A.122.2.1









Plastidic glycolate glycerate transporter, PLGG1, of 512 aas and 12 TMSs (Pick et al. 2013).  The last TMSs are homologous to the TMSs in several CidB and LrgB proteins of bacteria.  This plant protein may represent a fusion of the bacterial LrgA and LrgB proteins (Yang et al. 2012; Wang and Bayles 2013). Rice OsPLGG1 is the ortholgous plastidic glycolate/glycerate transporter, which is necessary for photorespiration and growth in rice (Shim et al. 2019).

Eukaryota
Viridiplantae
PLGG1 of Arabidopsis thaliana
*2.A.122.2.2









LrgB1 of 519 aas and 15 putative TMSs.

Eukaryota
Viridiplantae
LrgB1 of Oryza sativa
*2.A.122.2.3









LrgB2 of 458 aas and 12 - 14 TMSs.

Eukaryota
Viridiplantae
LrgB2 of Oryza sativa
*2.A.122.2.4









LrgB of 455 aas (Wang and Bayles 2013).

Eukaryota
Viridiplantae
LrgB of Chlamydomonas reinhardtii (Chlamydomonas smithii)
*2.A.122.2.5









LrgB1 of 455 aas (Wang and Bayles 2013).

Eukaryota
Bacillariophyta
LrgB1 of Thalassiosira pseudonana (Marine diatom) (Cyclotella nana)
*2.A.122.2.6









LrgB2 of 413 aas (Wang and Bayles 2013).

Eukaryota
Bacillariophyta
LrgB2 of Thalassiosira pseudonana (Marine diatom) (Cyclotella nana)
*2.A.122.3.1









Uncharacterized protein of 604 aas and 11 TMSs.

Eukaryota
Fungi
UP of Trichoderma harzianum