TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*2.A.127.1.1









PbgA (YejM) of 586 aas and 5 N-terminal TMSs with a C-terminal alkaline phosphatase-like domain (Dalebroux et al. 2015). The globular domains of PbgA resemble the structures of the arylsulfatase protein family and contains a novel core hydrophobic pocket that may be responsible for binding and transporting cardiolipin (Dong et al. 2016).  PhoPQ is activated within the intracellular phagosome environment of the host animal, where it promotes remodeling of the outer membrane and resistance to innate immune antimicrobial peptides. Maintenance of the PhoPQ-regulated outer membrane barrier requires PbgA, an inner membrane protein with a transmembrane domain essential for growth, and a periplasmic domain required for PhoPQ-activated increases in outer membrane cardiolipin. Fan et al. 2020 reported the crystal structure of cardiolipin-bound PbgA, adopting a transmembrane fold that features a cardiolipin binding site in close proximity to a long and deep cleft spanning the lipid bilayer. The end of the cleft extends into the periplasmic domain of the protein, which is structurally coupled to the transmembrane domain via a functionally critical C-terminal helix. In conjunction with a conserved putative catalytic dyad situated at the middle of the cleft, structural and mutational analyses suggest that PbgA is a multifunction membrane protein that mediates cardiolipin transport, a function essential for growth, and perhaps catalysis of an unknown enzymatic reaction (Fan et al. 2020).

Bacteria
Proteobacteria
PbgA of Salmonella enterica
*2.A.127.1.2









PbgA protein of 586 aas and 5 N-terminal TMSs. The 3-d structure of the C-terminal alkaline phosphatase-like domain has been solved (Dong et al. 2016).

Bacteria
Proteobacteria
PbgA of E. coli
*2.A.127.1.3









PbgA of 642 aas and 5 TMSs.

Bacteria
Proteobacteria
PbgA of Pseudomonas aeruginosa
*2.A.127.1.4









PbgA homologue of 662 aas and 5 N-terminal TMSs.

Bacteria
Proteobacteria
PbgA of Myxococcus xanthus
*2.A.127.1.5









Uncharacterized protein of 619 aas and 5 N-terminal TMSs.

Bacteria
Bacteroidetes
UP of Hymenobacter swuensis
*2.A.127.1.6









Uncharacterized protein of 896 aas and 11 or 12 TMSs.

Bacteria
Proteobacteria
UP of Hydrogenophaga palleronii
*2.A.127.1.7









Putative phosphoethanolamine transferase EptBof 518 aas and 3 N-terminal TMSs.

Bacteria
Proteobacteria
PE transferase of Thiotrichales bacterium
*2.A.127.1.8









Uncharacterized protein of 624 aas and 5 N-terminal TMSs.

Bacteria
Actinobacteria
UP of Rubrobacter radiotolerans
*2.A.127.1.9









Phosphatase PAP2 family protein of 231 aas and 5 TMSs.  This protein is homologous to the first half of TC# 2.A.127.1.6 which is not demonstrably homologous to other members of this family.

Bacteria
Proteobacteria
PAP2 family protein of Rhodoferax antarcticus
*2.A.127.1.10









Phosphatase PAP2 family protein of 263 aas and 5 TMSs in a 1 + 2 + 2 TMS arrangement.

Bacteria
Proteobacteria
PAP2 family protein of Tepidimonas taiwanensis
*2.A.127.1.11









LTA synthase family protein of 641 aas and 5 N-terminal TMSs in a 1 + 2 + 2 TMS arrangement.  This protein is homologous to TC# 2.A.1.127.1.5 throughout most of its length.  The 5 TMS transmembrane region is similar to several other members of this family as well as the second half of the 11 TMS transmembrane region plus the C-terminal hydropilic domain of TC# 2.A.1.127.1.6.

Bacteria
Proteobacteria
LTA synthase of Haemophilus influenzae
*2.A.127.1.12









Phosphatase PAP2 family protein of 307 aas and 6 TMSs, the first 3 TMSs are distant from each other while the last 3 TMSs are close to each other.

Bacteria
Verrucomicrobia
PAP2 family protein of Nibricoccus aquaticus
*2.A.127.1.13









Phosphatase PAP2 family protein of 252 aas and 6 TMSs in a 1 + 2 + 3 TMS arrangement.

Bacteria
Candidatus Cloacimonetes
PAP2 family protein of Candidatus Cloacimonetes bacterium
*2.A.127.1.14









Phosphatase PAP2 family protein of 467 aas and 6 TMSs in a 3 + 3 TMS arrangement.

Bacteria
Candidatus Aminicenantes
PAP2 family protein of Candidatus Aminicenantes bacterium (sediment metagenome)
*2.A.127.1.15









PAP2 (acid phosphatase) superfamily protein of 434 aas and 6 or 7 TMSs.

Bacteria
Nitrospirae
PAP2 family protein of Candidatus Magnetoovum chiemensis
*2.A.127.1.16









Phosphatase PAP2 family protein of 226 aas and 6 TMSs

Bacteria
Proteobacteria
PAP2 family protein of Solemya velum gill symbiont
*2.A.127.1.17









Phosphatase PAP2 family protein of 511 aas and 12 TMSs in a 3 + 3 + 3 + 3 TMS arrangement, where the first and third 3 TMS repeats are separated by larger loops than the second and fourth TMS repeats.

Bacteria
Proteobacteria
PAP2 family protein of Alphaproteobacteria bacterium
*2.A.127.1.18









Two domain protein with the N-terminal 6 TMS domain corresponding to those of TC families 2.A.127 and 9.B.105, and the second domain correspoonding to those of TC families 4.D.1 and 4.D.2.  These two domains are also found adjacent to each other in the same order in another TC entry with TC# 9.B.27.2.12. The protein is annotated in UniProt as an acidPPc domain-containing protein.

Bacteria
Proteobacteria
Two domain protein of Fulvimarina sp.