TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*2.A.13.1.1









Anaerobic C4-dicarboxylate antiporter (aspartate:fumarate antiporter).  Can catalyze both uptake and exchange (Zientz et al. 1996).

Bacteria
Proteobacteria
DcuA of E. coli (P0ABN5)
*2.A.13.1.2









Anaerobic C4-dicarboxylate uptake/efflux porter, DcuB. Also catalyzes substrate:substrate antiport (fumarate:malate or fumarate:succinate antiport), but it is also a cosensor for the sensor kinase, DcuS (Kleefeld et al. 2009; Bauer et al. 2011; Chen et al. 2014) It has 12 established TMSs where the loop between TMSs 11 and 12 is the sensor. A central water-filled cavity may provide the transport pathway. The sensory domain of DcuB is composed of cytoplasmic loop XI/XII and a membrane integral region with the regulatory residues Thr396/Asp398 and Lys353. Also transporter D-tartrate (Bauer et al. 2011).  Also transports D-tartrate (Kim et al. 2007).  The DcuB-DcuS interaction has been reviewed (Bauer et al. 2011; Chen et al. 2014) It has 12 established TMSs where the loop between TMSs 11 and 12 is the sensor. A central water-filled cavity may provide the transport pathway. The sensory domain of DcuB is composed of cytoplasmic loop XI/XII and a membrane integral region with the regulatory residues Thr396/Asp398 and Lys353. Also transporter D-tartrate (Bauer et al. 2011).  Also transports D-tartrate (Kim et al. 2007).  The DcuB-DcuS interaction has been reviewed (Unden et al. 2016).

Bacteria
Proteobacteria
DcuB of E. coli (P0ABN9)
*2.A.13.1.3









C4-dicarboxylate transporter, YhiT (probably transports succinate, fumarate, aspartate, asparagine, carbamoyl phosphate and dihydroorotate; Zaharik et al., 2007)

Bacteria
Proteobacteria
YhiT of Salmonella enterica
(Q8ZLD2)
*2.A.13.1.4









Uncharacterized C4-dicarboxylic acid transporter of 445 aas and 11 TMSs.

Bacteria
Actinobacteria
UP of Saccharothrix espanaensis
*2.A.13.1.5









Dicarboxylate transporter, DcuA of 445 aas and 11 TMSs.  Takes up aspartate under low (0.3%) oxygen conditions; is regulated in response to oxygen and nitrate mediated by the RacR/RacS sensor kinase/response regulatory pair (Wösten et al. 2017).

Bacteria
Proteobacteria
DcuA of Campylobacter jejuni
*2.A.13.1.6









Dicarboxylate transporter, DcuB of 474 aas and 11 TMSs.  Takes up aspartate and secretes succinate.  Subject to regulation in response to oxygen and nitrate, mediated by the sensor kinase/response regulator pair, RacR/RacS (Wösten et al. 2017).

Bacteria
Proteobacteria
DcuB of Campylobacter jejuni
*2.A.13.2.1









Uncharacterized protein of 386 aas and 10 TMSs.

Bacteria
Bacteroidetes/Chlorobi group
UP of Cardinium endosymbiont cEper1 of Encarsia pergandiella