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2.A.14.1.1
Lactate permease, LctP or LidP (substrates: L-lactate, D-lactate and glycolate) (Núñez et al. 2002).

Accession Number:P33231
Protein Name:LctP aka LldP aka B3603
Length:551
Molecular Weight:59168.00
Species:Escherichia coli [83333]
Number of TMSs:18
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Lactate, Glycolate

Cross database links:

Genevestigator: P33231
EchoBASE: EB1904
EcoGene: EG11961
eggNOG: COG1620
HEGENOM: HBG289840
DIP: DIP-10109N
RefSeq: AP_004188.1    NP_418060.1   
Entrez Gene ID: 948114   
Pfam: PF02652   
BioCyc: EcoCyc:LCTP-MONOMER    ECOL168927:B3603-MONOMER   
KEGG: ecj:JW3578    eco:b3603   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015129 F:lactate transmembrane transporter activity
GO:0015727 P:lactate transport

References (7)

[1] “Three overlapping lct genes involved in L-lactate utilization by Escherichia coli.”  Dong J.M.et.al.   8407843
[2] “Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes.”  Sofia H.J.et.al.   8041620
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “The gene yghK linked to the glc operon of Escherichia coli encodes a permease for glycolate that is structurally and functionally similar to L-lactate permease.”  Nunez M.F.et.al.   11283302
[6] “Transport of L-lactate, D-lactate, and glycolate by the LldP and GlcA membrane carriers of Escherichia coli.”  Nunez M.F.et.al.   11785976
[7] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNLWQQNYDP AGNIWLSSLI ASLPILFFFF ALIKLKLKGY VAASWTVAIA LAVALLFYKM 
61:	PVANALASVV YGFFYGLWPI AWIIIAAVFV YKISVKTGQF DIIRSSILSI TPDQRLQMLI 
121:	VGFCFGAFLE GAAGFGAPVA ITAALLVGLG FKPLYAAGLC LIVNTAPVAF GAMGIPILVA 
181:	GQVTGIDSFE IGQMVGRQLP FMTIIVLFWI MAIMDGWRGI KETWPAVVVA GGSFAIAQYL 
241:	SSNFIGPELP DIISSLVSLL CLTLFLKRWQ PVRVFRFGDL GASQVDMTLA HTGYTAGQVL 
301:	RAWTPFLFLT ATVTLWSIPP FKALFASGGA LYEWVINIPV PYLDKLVARM PPVVSEATAY 
361:	AAVFKFDWFS ATGTAILFAA LLSIVWLKMK PSDAISTFGS TLKELALPIY SIGMVLAFAF 
421:	ISNYSGLSST LALALAHTGH AFTFFSPFLG WLGVFLTGSD TSSNALFAAL QATAAQQIGV 
481:	SDLLLVAANT TGGVTGKMIS PQSIAIACAA VGLVGKESDL FRFTVKHSLI FTCIVGVITT 
541:	LQAYVLTWMI P