TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*2.A.16.1.1









Tellurite resistance protein, TehA.  Encoded in an operon with the gene for a tellurite S-adenosylmethionine-dependent methyl transferase.  Together they confer tellurite resistance (Moraes and Reithmeier 2012).

Bacteria
Proteobacteria
TehA of E. coli
*2.A.16.1.2









Tellurite resistance protein TehA homologue. An anion channel involved in tellurite resistance.  A quasi-symmetrical homotrimer in which each subunit has 10 TMSs and forms a channel.  The crystal structure is known at 1.2 A resolution (Chen et al. 2010).  The helices are arranged from helical hairpin pairs to form a central 5-helix transmembrane pore that is gated by a conserved phenylalanine residue.  Gating is controlled by kinase activation.  Selectivity for various anions may be a function of the energetic cost of ion dehydration (Chen et al. 2010).

Bacteria
Proteobacteria
Tellurite resistance protein tehA homologue of Haemophilus influenzae
*2.A.16.2.1









Mae1 malate transport protein
Eukaryota
Fungi
Mae1 of Schizosaccharomyces pombe
*2.A.16.2.2









The ATP-dependent subtelomeric helicase, RecQ (2100 aas with a 5 TMS N-terminal domain (residues 43-210). 94% identical to 2.A.16.2.1 (malate transporter) of the same species.
Eukaryota
Fungi
RecQ of Schizosaccharomyces pombe (Q5EAK4)
*2.A.16.3.1









The sulfite efflux (sulfite sensitivity) protein, SSU1. Expression is controlled by the FZF1-4 transcriptional activator; only free sulfite (not complexed sulfite) is exported (Park and Bakalinsky, 2000). Can also export nitrite and nitrate (Cabrera et al. 2014).  SSU1 has a putative 10 TMS topology in a (S-L)5 arrangement where S= a small putative TMS and L= a large TMS. 

Eukaryota
Fungi
SSU1 of Saccharomyces cerevisiae (P41930)
*2.A.16.3.2









Sulfite, nitrate exporter of 384 aas, Ssu1 (Cabrera et al. 2014).

Eukaryota
Fungi
Ssu1 of Pichia angusta (Yeast) (Hansenula polymorpha)
*2.A.16.3.3









Sulfite/nitrate exporter of 392 aas, Ssu2 (Cabrera et al. 2014).

Eukaryota
Fungi
Ssu2 of Pichia angusta (Yeast) (Hansenula polymorpha)
*2.A.16.4.1









The unknown homologue, UnkH (same topology as 2.A.16.3.1)

Eukaryota
Fungi
UnkH of Aspergillus niger (A2QYD7)
*2.A.16.4.2









Sulfite efflux pump, Ssul (Sulfite sensitivity protein) (Lechenne et al., 2007).
Eukaryota
Fungi
Ssul of Arthroderma benhamiea (A3R044)
*2.A.16.4.3









Sulfite efflux pump, Ssul (Lechenne et al., 2007).
Eukaryota
Fungi
Ssul of Aspergillus fumigatus (Q2TJJ2)
*2.A.16.4.4









Uncharacterized transporter MJ0762
Archaea
Euryarchaeota
MJ0762 of Methanocaldococcus jannaschii
*2.A.16.4.5









TDT homolouge

Archaea
Crenarchaeota
TDT homologue of Sulfolobus acidocaldarius
*2.A.16.4.6









TDT homologue

Bacteria
Actinobacteria
TDT homologue of Streptomyces coelicolor
*2.A.16.5.1









The plant guard cell S (Slow)-type anion channel, SLAC1 (based on activation kinetics of anion channel currents in response to voltage changes); functions in stomatal signalling, controls turgor pressure, and regulates the exchange of water and CO2 (Chen et al. 2010). Also called carbon dioxide insensitive (CDI3) and ozone sensitive (OZS1) (Kollist et al., 2011). Heterotrimeric G proteins regulate guard cell ion channels (Zhang, 2011). Evolutionary studies have been reported (Dreyer et al. 2012). The transmembrane region of guard cell SLAC1 channels detect CO2 signals via an abscisic acid (ABA)-independent pathway (Yamamoto et al. 2016).  SLAC1 is activated by the protein kinase OST1 (OPEN STOMATA 1), the Ca2+-dependent protein kinases (CPKs), the GHR1 (GUARD CELL HYDROGEN PEROXIDE-RESISTANT 1) transmembrane receptor-like protein (TC# 1.A.87.2.8), or the PYL5 abscisic acid (ABA) receptor (Q9FLB1)  (Wang et al. 2017).

Eukaryota
Viridiplantae
SLAC1 of Arabidopsis thaliana
(Q9LD83)
*2.A.16.5.2









Slow anion channel homologue-3, SLAH3; nitrate is both a substrate and a gate opener (Geiger et al. 2011).

Eukaryota
Viridiplantae
SLAH3 of Arabidopsis thaliana
*2.A.16.6.1









TDT homologue, TehA of 302aas and 10 TMSs

Bacteria
Firmicutes
TehA of Streptococcus pyogenes (Q9A061)
*2.A.16.6.2









TehA homologue of 314aas and 10 TMSs

Bacteria
Firmicutes
TehA of Clostridium butyricum (C4IKV8)