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2.A.18.5.4
Vesicular inhibitory amino acid transporter (GABA and glycine transporter; Solute carrier family 32 member 1; Vesicular GABA transporter; VGAT; hVIAAT).  Probably functions by GABA:H+ antiport (Farsi et al. 2016). It localizes to the distal kidney tubule epithelia, especially in the inner medulla and basal portions of the lateral plasma membranes, but not in vesicles or vacuoles (Sakaew et al. 2018).

Accession Number:Q9H598
Protein Name:Vesicular inhibitory amino acid transporter
Length:525
Molecular Weight:57415.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Cytoplasmic vesicle membrane1 / Multi-pass membrane protein2
Substrate Gamma-aminobutyric acid, Amino acids, H+

Cross database links:

Genevestigator: Q9H598
eggNOG: NOG294245
HEGENOM: HOG000220837
Entrez Gene ID: 140679   
Pfam: PF01490   
Drugbank: Drugbank Link   
KEGG: hsa:140679   

Gene Ontology

GO:0051286 C:cell tip
GO:0061202 C:clathrin sculpted gamma-aminobutyric acid transport vesicle membrane
GO:0044316 C:cone cell pedicle
GO:0030425 C:dendrite
GO:0044292 C:dendrite terminus
GO:0060077 C:inhibitory synapse
GO:0016021 C:integral to membrane
GO:0044306 C:neuron projection terminus
GO:0005886 C:plasma membrane
GO:0030672 C:synaptic vesicle membrane
GO:0015495 F:gamma-aminobutyric acid:hydrogen symporter activity
GO:0015187 F:glycine transmembrane transporter activity
GO:0007568 P:aging
GO:0006811 P:ion transport
GO:0007269 P:neurotransmitter secretion
GO:0055085 P:transmembrane transport

References (5)

[1] “Expression of the vesicular inhibitory amino acid transporter in pancreatic islet cells: distribution of the transporter within rat islets.”  Chessler S.D.et.al.   12031963
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The DNA sequence and comparative analysis of human chromosome 20.”  Deloukas P.et.al.   11780052
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Cellular localization of the vesicular inhibitory amino acid transporter in the mouse and human retina.”  Jellali A.et.al.   12115694

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MATLLRSKLS NVATSVSNKS QAKMSGMFAR MGFQAATDEE AVGFAHCDDL DFEHRQGLQM 
61:	DILKAEGEPC GDEGAEAPVE GDIHYQRGSG APLPPSGSKD QVGGGGEFGG HDKPKITAWE 
121:	AGWNVTNAIQ GMFVLGLPYA ILHGGYLGLF LIIFAAVVCC YTGKILIACL YEENEDGEVV 
181:	RVRDSYVAIA NACCAPRFPT LGGRVVNVAQ IIELVMTCIL YVVVSGNLMY NSFPGLPVSQ 
241:	KSWSIIATAV LLPCAFLKNL KAVSKFSLLC TLAHFVINIL VIAYCLSRAR DWAWEKVKFY 
301:	IDVKKFPISI GIIVFSYTSQ IFLPSLEGNM QQPSEFHCMM NWTHIAACVL KGLFALVAYL 
361:	TWADETKEVI TDNLPGSIRA VVNIFLVAKA LLSYPLPFFA AVEVLEKSLF QEGSRAFFPA 
421:	CYSGDGRLKS WGLTLRCALV VFTLLMAIYV PHFALLMGLT GSLTGAGLCF LLPSLFHLRL 
481:	LWRKLLWHQV FFDVAIFVIG GICSVSGFVH SLEGLIEAYR TNAED