TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*2.A.20.1.1









Low affinity Pi or phosphate-zinc complex uptake transporter #1, PitA (Km=2 μM) (Me·Pi:H+ symporter) (Beard et al. 2000; Jackson et al. 2008). Also transports tellurite (TeO32-) slowly (Elías et al. 2012; Borghese et al. 2016).

Bacteria
Proteobacteria
PitA of E. coli (P0AFJ7)
*2.A.20.1.2









Low affinity Pi transporter #2, PitB (Km=30 μM) PitB, like PitA is also a Me·Pi:H+ symporter (Borghese et al. 2016)

Bacteria
Proteobacteria
PitB of E. coli
*2.A.20.1.3









Probable low-affinity inorganic phosphate transporter, Pit

Bacteria
Actinobacteria
Pit of Mycobacterium bovis
*2.A.20.1.4









Probable low-affinity inorganic phosphate transporter
Bacteria
Proteobacteria
Pit of Rhizobium meliloti
*2.A.20.1.5









Putative low affinity Pi transporter PitH1, Sco4138 (Santos-Beneit et al. 2008).

Bacteria
Actinobacteria
PitH1 of Streptomyces coelicolor.
*2.A.20.1.6









Putative low affinity Pi transporter PitH2, Sco1845 (Santos-Beneit et al., 2008).

Bacteria
Actinobacteria
PitH2 of Streptomyces coelicolor.
*2.A.20.1.7









Low affinity inorganic phosphate uptake porter of 335 aas, PitA (Kim et al. 2014; Mechler L, ... Bertram R, personal communication).

Bacteria
Firmicutes
PitA of Staphylococcus aureus
*2.A.20.2.1









Pi-repressible Pi:Na+ symporter
Eukaryota
Fungi
Pho4 of Neurospora crassa
*2.A.20.2.2









High affinity Pi:Na+ symporter
Eukaryota
Fungi
Pho89 (YBR296c) of Saccharomyces cerevisiae
*2.A.20.2.3









Gibbon ape leukemia virus receptor 2/sodium-dependent phosphate transporter, Pi:Na+ symporter, PiT2, PiT-2, GLVR2, SLC20A2. Mapping of the minimal transporting unit suggested a structure universal to all PiT-related proteins (Battger and Pedersen, 2011).The protein can transport Pi in the absence of Na+, and mutations allow Na+ transport in the absence of Pi. Transmembrane amino acids E(55) and E(575) appear to be responsible for linking Pi import to Na+symport (Bøttger et al. 2006).

transport in PiT2.
Eukaryota
Metazoa
SLC20A2 of Homo sapiens
*2.A.20.2.4









Low affinity Pi transporter, PHT2, Pht2;1, Pht2,1 of 587 aas (Młodzińska and Zboińska 2016).

Eukaryota
Viridiplantae
Pht2;1 of Arabidopsis thaliana
*2.A.20.2.5









The Pi:Na+ symporter, PfPit (669 aas; Saliba et al., 2006)

Eukaryota
Apicomplexa
PfPit of Plasmodium falciparum (Q7YUD6)
*2.A.20.2.6









The Pi:(Na+)2 symporter, GLVR1, PiT1 or PiT-1 (Ravera et al., 2007). Mutating the conserved loop region between TMSs 2 and 3 alterred the binding properties of the transporter for Na+/Li+ and phosphate/arenate (Ravera et al. 2013).

Eukaryota
Metazoa
Pit1 of Xenopus tropicalis (Q5BL44)
*2.A.20.2.7









Na+-dependent phosphate transporter 1 (PiT-1). Gibbon ape leukemia virus receptor 1 (GLVR-1), Slc20A1 (KM=24μM).  The protein has an experimentally tested 12 TMS topology (Farrell et al. 2009).  A knock-out mutation of the mouse orthologue results in abnormal endocytosis in the yolk sac visceral endoderm and embyonic death at the 12.5 day stage (Wallingford and Giachelli 2014).

Eukaryota
Metazoa
SLC20A1 of Homo sapiens
*2.A.20.2.8









Na+:Pi transporter, SPT1 (Li et al., 2011)

Eukaryota
Viridiplantae
SPT1 of Dunaliella viridis (A7U4W2)
*2.A.20.2.9









Putative phosphate permease HP_1491
Bacteria
Proteobacteria
HP_1491 of Helicobacter pylori
*2.A.20.2.10









Phosphate:sodium symporter of 576 aas, Pho89 (Ahn et al. 2009).

Eukaryota
Fungi
Pho89 of Komagataella pastoris (Yeast) (Pichia pastoris)
*2.A.20.2.11









Phosphate transporter of 601 aas and 12 TMSs. Pho4.

Eukaryota
Kinetoplastida
Pho4 of Trypanosoma cruzi
*2.A.20.3.1









Putative Na+-dependent Pi transporter
Archaea
Euryarchaeota
Npt of Methanococcus jannaschii
*2.A.20.3.2









Low affinity high velocity phosphate transporter, PitA if 320 aas (McCarthy et al. 2014).

Archaea
Crenarchaeota
PitA of Metallosphaera cuprina
*2.A.20.3.3









Low affinity phosphate transporter, PitA of 328 aas

Archaea
Crenarchaeota
PitA of Sulfolobus solfataricus
*2.A.20.3.4









Low affinity phosphate carrier, PitA of 309 aas.

Archaea
Euryarchaeota
PitA of Archaeoglobus profundus
*2.A.20.4.1









Bacteria
Firmicutes
CysP (YlnA) of Bacillus subtilis