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2.A.22.1.11
Serotonin transporter, SERT, of 670 aas and 12 TMSs.  it is subject to allosteric regulation involving 2 and possibly 3 distinct allosteric binding sites (Neubauer et al. 2006). Allosteric effectors include the transport inhibitors, duloxetine, RTI-55 and (S)-citalopram, which are antidepressants, and sometimes anti-anxiety and anti-pain medications in humans.

Accession Number:Q6PWI2
Protein Name:Transporter
Length:670
Molecular Weight:74427.00
Species:Gallus gallus (Chicken) [9031]
Number of TMSs:11
Substrate

Cross database links:

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  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MENKATSNET QPLTSKKGIS DCNEGEDCKE NGLLIRNPKS ALRLVDDGNK VHPGQGDKEE 
61:	AAQISNGYSG VQSSGPCSGM GEAEDAQCTA PAATTTTTTT TSTTCGAEGQ QQLMELGDRE 
121:	TWSKKIDFLL SVIGYAVDLG NVWRFPYICY QNGGGAFLIP YTIMAIFGGI PLFYMELALG 
181:	QYHRNGCISI WRKICPIFKG IGFAICIIDL YVASYYNTIM AWVFYYLVSS FTTELPWTSC 
241:	NNAWNTGNCT TYFSKDNISW ALHSISPAEE FYTRQVLQVH RSNGLDDLGG ISWQLTLCLL 
301:	LIFIIVYFSI WKGVKTSGKV VWVTATFPYV ILFILLVRGA TLPGAWRGVL YYLKPEWQKL 
361:	LATEVWVDAA AQIFFSLGPG FGVLLAYASY NKFHNNCYQD ALVTSTVNCL TSFVSGFVIF 
421:	TVLGYMAEMR NEDVSEVAKD MGPSLLFITY AEAIANMPAS TFFAIIFFLM LLTLGLDSTF 
481:	AGLEGVITGV LDEFPHVWSK RREFFVLGLI IICFLGSLAT LTFGGAYVVK LFEEYATGPA 
541:	VLTVVFLEAV AVAWFYGITQ FCNDVKEMLG FAPGWYWRVC WVAISPIFLL FVTCSFLSNP 
601:	PELRLFDYNY PYWTTVVGYC IGTSSIICIP IYMAYRLIIT PGTLKERILK SITPETATEI 
661:	PFGDIRMNAV