TCDB » SEARCH

« See all members of the family

2.A.22.4.1 High affinity tryptophan:Na⁺ symporter, TnaT, of 501 aas and 12 TMSs (Androutsellis-Theotokis et al., 2003). The K_m for Tryptophan is 145 nM; tryptamine and serotonin weakly inhibited with K_i values of 200 and 440 μM, respectively.
Accession Number:	O50649
Protein Name:	TnaT
Length:	501
Molecular Weight:	54750.00
Species:	Symbiobacterium thermophilum [2734]
Number of TMSs:	12
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate	tryptophan, Na+

HEGENOM:	HBG702834
RefSeq:	YP_074271.1
Entrez Gene ID:	2980189
Pfam:	PF00209
BioCyc:	STHE292459:STH442-MONOMER
KEGG:	sth:STH442
Gene Ontology GO:0005887 C:integral to plasma membrane GO:0005328 F:neurotransmitter:sodium symporter activity GO:0006836 P:neurotransmitter transport
References (2) [1] “Cloning, nucleotide sequences, and overexpression in Escherichia coli of tandem copies of a tryptophanase gene in an obligately symbiotic thermophile, Symbiobacterium thermophilum.” Hirahara T.et.al. 1339259 [2] “Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism.” Ueda K.et.al. 15383646

BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
CDD Search (Conserved Domain Database)
Search COGs (Clusters of Orthologous Groups of proteins)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MEAQRDQWKS RSGFIFATIG AAVGLGNFWR FPFMAYQNGG GAFLLPYFVA LLTAGVPLMI 
61:	LEFGFGHKMR TATITAFKKL NRRFEWIGWW QITVPVVVVT FYSVIISWSL RYLIFSFTQA 
121:	WGDDPGTFFS SDFLGITSGP LELGGLRWGI FAAVAVVWFA NYYISAQGIS GGIEKACKIM 
181:	TPFLIVAMLI FVIRGITLPG ATYGLNYFLN PDFSKIMDPG VWVAAYSQVF FSTTLAVGVM 
241:	IAYASYVPED SDLANNAFIT VFANSSFDFM AGLAVFSTLG YAAVTAGVPF EEMAVAGPGV 
301:	AFVAFPKAIS MLPGPTWLQS LFGILFFSAL LLAGISSSIS QMESFASAVI DRFGVDRKKL 
361:	LGWFSLIGFA FSALFATGAG VHILDIVDHF VGSYAIAILG LVEAIVLGYI MGTARIREHV 
421:	NLTSDIRVGM WWDVLVKYVT PVLLGYNILS NFISEFREPY AGYPTGALVL FGWVVAIAMF 
481:	GTSLFMQWRS QQLDVTGGEV G

2.A.22.4.1
High affinity tryptophan:Na⁺ symporter, TnaT, of 501 aas and 12 TMSs (Androutsellis-Theotokis et al., 2003). The K_m for Tryptophan is 145 nM; tryptamine and serotonin weakly inhibited with K_i values of 200 and 440 μM, respectively.

Cross database links:

Gene Ontology

References (2)

External Searches:

Analyze:

2.A.22.4.1High affinity tryptophan:Na+ symporter, TnaT, of 501 aas and 12 TMSs (Androutsellis-Theotokis et al., 2003). The Km for Tryptophan is 145 nM; tryptamine and serotonin weakly inhibited with Ki values of 200 and 440 μM, respectively.

Cross database links:

Gene Ontology

References (2)

External Searches:

Analyze:

2.A.22.4.1
High affinity tryptophan:Na⁺ symporter, TnaT, of 501 aas and 12 TMSs (Androutsellis-Theotokis et al., 2003). The K_m for Tryptophan is 145 nM; tryptamine and serotonin weakly inhibited with K_i values of 200 and 440 μM, respectively.