TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*2.A.28.1.1









Organic acid/(conjugated) bile acid (taurocholate):Na+ symporter. Taurine conjugates > glycine conjugates > unconjugated bile salts.
Eukaryota
Metazoa
Liver bile acid uptake system of Rattus norvegicus
*2.A.28.1.2









Liver/ileal bile acid:Na+ symporter, ASBT or NTCP (SLC10A2) (essential for liver or intestinal bile acid transport and homeostasis (Rao et al., 2008). TMS4 forms part of the substrate translocation pathway (Khantwal and Swaan, 2008); TMS7 plays a role in substrate binding and translocation (González et al., 2012); TMS1 contributes to substrate translocation and protein stability (da Silva et al., 2011), and TMS2 coordinates Na+ translocation (Sabit et al. 2013).  NTCP serves as the Hepatitis B Virus (HBV) receptor, and drugs developed to target NTCP induce autophagy and may provide therapy for HBV (Zhang et al. 2015). Decreased activity leads to luminal bile salt conecentrations and either increased eletrolyte secretion or decresased reabsolption van der Mark et al., 2014. Function and stability depend on N-glycosylation (Muthusamy et al. 2015).  Specific inhibitors are known (Slijepcevic and van de Graaf 2017).

Eukaryota
Metazoa
NTCP of Homo sapiens
*2.A.28.1.3









The organic anion:Na+ symporter, SOAT (transports estrone-3-sulfate (Km= 31 μM) and dehydropiandrosterone sulfate (Km = 30 μM) but not taurocholate, estradiol-17β-glucuronide or ouabain) (Geyer et al., 2004)
Eukaryota
Metazoa
SOAT of Rattus norvegicus
(Q70EX6)
*2.A.28.1.4









The organic anion:Na+ symporter, SOAT (probable paralogue of 2.A.28.1.3); a 7 TMS protein with the N-terminus out and the C-terminus in. Transports dehydroepiandrosterone sulfate, estrone-3-sulfate, and pregnenolone sulfate with Km values of 30, 12 and 11 μM, respectively. Sulfoconjugated taurolithocholate is also a substrate. Cholate, taurocholate and chenodeoxycholate are not substrates. (Geyer et al., 2007).
Eukaryota
Metazoa
SLC10A6 of Homo sapiens
*2.A.28.1.5









solute carrier family 10 (sodium/bile acid cotransporter family), member 3

Eukaryota
Metazoa
SLC10-3 of Bos taurus (Q0V8N6)
*2.A.28.1.6









solute carrier family 10 (sodium/bile acid cotransporter family), member 5

Eukaryota
Metazoa
SLC10A5 of Homo sapiens
*2.A.28.1.7









Solute carrier family 10 (sodium/bile acid cotransporter family), member 4.  The rat orthologue is found in cholinergic neurons of the brain together with the vesicular acetyl choline transporter, VAChT (TC# 2.A.1.2.28), and the high affinity choline transporter, CHT1 (TC#s 2.A.21.8.1 & 2) (Geyer et al. 2008).  It is a protease-activated bile acid transporter (Abe et al. 2013).  It has also been reported to be a vesicular monoaminergic and cholinergic associated transporter that is important for dopamine homeostasis and neuromodulation in vivo, and it may play a role in neurotransmitter release at the neuromuscular junction (Larhammar et al. 2015; Patra et al. 2015). It's loss in mice results in cognitive impairment (Melief et al. 2016).

Eukaryota
Metazoa
SLC10A4 of Homo sapiens
*2.A.28.1.8









P3 protein (Solute carrier family 10 member 3)
Eukaryota
Metazoa
SLC10A3 of Homo sapiens
*2.A.28.1.9









Sodium/bile acid cotransporter (Cell growth-inhibiting gene 29 protein; Na+/bile acid cotransporter; Na+/taurocholate transport protein; NTCP; Solute carrier family 10 member 1). Transports steroids and xenobiotics, including HMG-CoA reductase inhibiitors (statins). This protein is the hepatitis B and D virus receptor (Yan et al. 2012). Specific inhibitors are known (Slijepcevic and van de Graaf 2017).

Eukaryota
Metazoa
SLC10A1 of Homo sapiens
*2.A.28.1.10









BASS family homologue

Bacteria
Proteobacteria
BASS family homologue of Myxococcus xanthus
*2.A.28.2.1









The chloroplastic glucosinolate uptake porter, BAT5 (Gigolashvili et al., 2009) [glucosinolates are thioglucosides of amino acid derivatives. These bitter natural pesticides are present in most plants of the order Brassicales among others].

Eukaryota
Viridiplantae
BAT5 of Arabidopsis thaliana (Q3EA49)
*2.A.28.2.2









Chloroplast envelope membrane pyruvate:Na+ symporter, called Bile acid:sodium symporter, protein 2, BASS2 (widely distributed in all land plants tested) (Furumoto et al., 2011).

Eukaryota
Viridiplantae
BASS2 of Flaveria trinervia (E0D3H5)
*2.A.28.2.3









Chloroplast envelope membrane pyruvate:Na+ symporter, BASS2. (Orthologous to 2.A.28.2.2) (Furumoto et al., 2011)

Eukaryota
Viridiplantae
BASS2 pf Arabidopsis thaliana (Q1EBV7)
*2.A.28.2.4









Na+:bile acid symporter (AstB). The 3-d structure is available (3ZUX).

Bacteria
Proteobacteria
AstB of Neisseria meningitidis (Q9K0A9)
*2.A.28.2.5









Putative Na+ symporter

Bacteria
Firmicutes
YqcL of Paenibacillus sp. JDR-2 (C6CWW0)
*2.A.28.2.6









Probable macrolide resistance porter (very similar to the orthologue in B. brevis) (Margolles et al. 2005).

Bacteria
Actinobacteria
Macrolide resistance protein of Bifidobacterium longum
*2.A.28.2.7









Putative Na+ symporter (10 TMSs)

Archaea
Euryarchaeota
Putative Na+ symporter of Halomicrobium mukohataei (C7NY93)
*2.A.28.2.8









Putative integral membrane protein

Bacteria
Actinobacteria
*2.A.28.2.9









Sodium bile acid symporter family protein, ASBT, of 307 aas and 10 TMSs.  The 3-d structure has been solved (4N7W) (Zhou et al. 2014). This structure has been used to model the yeast Acr3  protein (TC# 2.A.59.1.1) which is in a distinct family of the BART superfamily (Wawrzycka et al. 2016).

Bacteria
Proteobacteria
ASBT of Yersinia frederiksenii
*2.A.28.3.1









Solute carrier family 10, member 7 protein (358 aas; 10 established TMSs with the N- and C-termini in the cytoplasm (Godoy et al. 2007)) (Zou et al., 2005).  Present in the plasma membrane.  Slc10a7 KO mice exhibit moderate skeletal dysplasia (osteochondrodyplasia), characterized by markedly shortened and mildly bowed limbs (Brommage et al. 2014).

Eukaryota
Metazoa
SLC10A7 of Homo sapiens
*2.A.28.3.2









Putative Na+-dependent transporter
Eukaryota
Viridiplantae
Putative transporter of Arabidopsis thaliana (Q9LYM5)
*2.A.28.3.3









Putative Na+-dependent transporter

Bacteria
Proteobacteria
Putative transporter of Paracoccus denitrificans
*2.A.28.3.4









Putative Na+-dependent transporter, YfeH (332 aas; 7-10 TMSs)
Bacteria
Proteobacteria
YfeH of E. coli (P39836)
*2.A.28.3.5









Putative Na+-dependent transporter (322 aas; 8-10 TMSs)
Bacteria
Chlamydiae/Verrucomicrobia group
Transporter of Lentisphaera araneosa (A6DUG7)
*2.A.28.3.6









Fusion Protein of 928aas: N-terminal Cysteine proteinase/Cathepsin F (residues 1-578/Peptidase CIA family) C-terminal BART sugar family domain (579-928).

Eukaryota
Viridiplantae
Protease/transporter fusion protein of Ostreococcus tauri (Q01E11)
*2.A.28.3.7









RCh1p transporter (SLC10 family). Regulates cytosolic Ca2+ homeostasis (Jiang et al., 2012).  Rch1p is part of the low-affinity calcium uptake system (LACS) system and does not functionally interact with Cch1p (Alber et al. 2013).

Eukaryota
Fungi
RCh1p of Candida albicans (Q59UQ7)
*2.A.28.4.1









Uncharacterized protein of 360 aas with an N-terminal hydrophobic domain of 4 - 5 TMSs homologous to members of this family.  The C-terminal hydrophilic domain may be related to TC# 1.C.96, and 1.C.96 may be related to 1.C.5 in the aerolysin superfamily.

UP of Crassostrea gigas (Pacific oyster) (Crassostrea angulata)