TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*2.A.29.1.1









Mitochondrial ATP/ADP antiporter (SLC25A5 (300150)). Facilitates exchange of ADP and ATP between the cytosol and mitochondria (inhibited by carboxyatractyloside and bongkrekate) (Clémençon et al. 2013).  Modification of lysyl residues with fluorescamine induces Ca2+ permeability (Buelna-Chontal et al. 2014).

Eukaryota
Metazoa
SLC25A5 of Homo sapiens
*2.A.29.1.2









Mitochondrial ADP/ATP carrier 1 (AAC1); ADP/ATP translocase 1; adenine nucleotide translocator 1 (ANT1); adPEO, Sengers syndrome (SLC25A4)
Eukaryota
Metazoa
SLC25A4 of Homo sapiens
*2.A.29.1.3









Adenine nucleotide transporter, ANT, or ATP:ADP carrier AAC1 (one of three paralogues).  Transports heme and heme precursor protoporphyrin IX (PP IX) as well as ATP and ADP (Azuma et al. 2008).

Eukaryota
Fungi
AAC1 of Saccharomyces cerevisiae (P04710)
*2.A.29.1.4









The Hydrogenosome ADP/ATP carrier (Van der Giezen et al., 2002)
Eukaryota
Fungi
Hydrogenosome ADP/ATP carrier of Neocallimastix frontalis (AAK 71468)
*2.A.29.1.5









ADP (Km = 40 µM)/ATP (Km = 100 µM) antiporter, ACC1 (three isoforms, AAC1, 2 and 3 were characterized where AAC3 has higher affinities (10-22 µM) (Haferkamp et al., 2002).
Eukaryota
Viridiplantae
ACC1 of Arabidopsis thaliana
(P31167)
*2.A.29.1.6









The Endoplasmic Reticular Adenine Nucleotide Transporter, ER-ANT1 (probable ATP:ADP exchanger; Leroch et al., 2008)
Eukaryota
Viridiplantae
ER-ANT1 of Arabidopsis thaliana (Q0WQJ0)
*2.A.29.1.7









ADP:ATP carrier 2, Aac2 (Lethal with loss of Sal1, (2.A.29.23.2) but independent of its AAC activity (Kucejova et al., 2008)).  The x-ray structure suggests a novel domain-based alternating-access transport mechanism (Ruprecht et al. 2014).

Eukaryota
Fungi
Aac2 of Saccharomyces cerevisiae (P18239)
*2.A.29.1.8









Mitochondrial ADP/ATP carrier.

Eukaryota
Metazoa
SLC25A31 of Homo sapiens
*2.A.29.1.9









ADP/ATP carrier #3, AAC3 (90% identical to 2.A.29.1.7) (#2)). Prolines in TMSs 1,3, and 5 are important for function (Babot et al., 2012).  The x-ray structure suggests a novel domain-based alternating-access transport mechanism (Ruprecht et al. 2014).  Although the transporter catalyzes the translocation of substrate, the substrate also facilitates interconversion between alternating states (Brüschweiler et al. 2015).

Eukaryota
Fungi
ADP/ATP exchanger-3 (ACC3) of Saccharomyces cerevisiae (P18238)
*2.A.29.1.10









solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6

Eukaryota
Metazoa
SLC25A6 of Homo sapiens
*2.A.29.2.1









Oxoglutarate/malate antiporter. Also transports porphyrin derivatives: Fe-protoporphyrin IX, coproporphyrin III, hemin, etc. (Kabe et al., 2006). Plays roles in the malate-aspartate shuttle, the oxoglutarate-isocitrate shuttle and gluconeogenesis.  Functional residues have been identified (Cappello et al. 2007).

Eukaryota
Metazoa
Oxoglutarate/malate carrier of Bos taurus
*2.A.29.2.2









Dicarboxylate (succinate/fumarate/ malate/α-ketoglutarate/ oxaloacetate) antiporter
Eukaryota
Metazoa
Dicarboxylate transporter of Rattus norvegicus
*2.A.29.2.3









Dicarboxylate:Pi antiporter (Pi, malate, succinate, oxaloacetate, sulfate, sulfite)
Eukaryota
Fungi
Dicarboxylate:Pi antiporter of Saccharomyces cerevisiae
*2.A.29.2.4









Mammalian oxodicarboxylate carrier (ODC; SLC25A21; 607571) (transports C5-C7 oxodicarboxylates including 2-oxoadipate and 2-oxoglutarate in an antiport reaction; also transports less well: pimelate, 2-oxopimelate, 2-amino adipate, oxaloacetate, and citrate) (Defects cause 2-oxoadipate acidemia, an inborn error of metabolism)

Eukaryota
Metazoa
SLC25A21 of Homo sapiens
*2.A.29.2.5









2-oxodicarboxylate carrier 2 (ODC2) (transports the same substrates as human ODC except that 2-amino adipate is not transported while malate is) (Palmieri et al. 2006).

Eukaryota
Fungi
ODC2 of Saccharomyces cerevisiae (Q99297)
*2.A.29.2.6









Plant dicarboxylate/tricarboxylate carrier, DTC, transports dicarboxylates (such as malate, oxaloacetate, oxoglutarate, and maleate) and tricarboxylates (such as citrate, isocitrate, cis-aconitate, and trans-aconitate)
Eukaryota
Viridiplantae
DTC of Nicotiana tabacum
*2.A.29.2.7









Mitochondrial dicarboxylate carrier (DIC; SLC25A10; 606794) transports malate, succinate, phosphate, sulfate, thiosulfate

Eukaryota
Metazoa
SLC25A10 of Homo sapiens
*2.A.29.2.8









2-oxodicarboxylate carrier 1 (ODC1) transports C5-C7 oxodicarboxylic acid (2-oxoadipate, 2-oxoglularate, adipate, glutarate, 2-oxopimelate, oxaloacetate, citrate and malate) (functions by a strict antiport mechanism (Palmieri et al., 2001).
Eukaryota
Fungi
ODC1 of Saccharomyces cerevisiae (Q03028)
*2.A.29.2.9









The dicarboxylate carriers, DIC1 (transports malate, oxaloacetate and succinate as well as phosphate, sulfate and thiosulfate at high rates: 2-oxoglutarate is a poor substrate (Palmieri et al., 2007)).

Eukaryota
Viridiplantae
DIC1 of Arabidopsis thaliana (Q9SJY5)
*2.A.29.2.10









The dicarboxylate-tricarboxylate carrier (PfDTC) catalyzes oxoglutarate-malate, oxoglutarate-oxaloacetate, or oxoglutarate-oxoglutarate  exchange (Nozawa et al., 2011).

Eukaryota
Apicomplexa
DTC of Plasmodium falciparum (Q8IB73)
*2.A.29.2.11









solute carrier family 25 (mitochondrial carrier; oxoglutarate/malate carrier), member 11

Eukaryota
Metazoa
SLC25A11 of Homo sapiens (Q9CR62)
*2.A.29.2.12









Solute carrier family 25 member 52 (Mitochondrial carrier triple repeat protein 2)
Eukaryota
Metazoa
SLC25A52 of Homo sapiens
*2.A.29.2.13









Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP) (Solute carrier family 25 member 11)
Eukaryota
Metazoa
SLC25A11 of Homo sapiens
*2.A.29.2.14









Solute carrier family 25 member 51 (Mitochondrial carrier triple repeat protein 1)
Eukaryota
Metazoa
SLC25A51 of Homo sapiens
*2.A.29.3.1









Uncoupling protein (H+; halide anions; protonated or anionic fatty acids)
Eukaryota
Metazoa
Uncoupling carrier of Bos taurus
*2.A.29.3.2









Mitochondrial brown fat uncoupling protein 1 (UCP1) (thermogenin); obesity protein (SLC25A7); mediates adaptive thermogenesis Azzu and Brand, 2009).  Transports protons and chloride ions; activated by fatty acids and inhibited by purine nucleotides (Hoang et al. 2012).  Functions as a long-chain fatty acid (LCFA) anion/H+ symporter, but the LCFA anion can don dissociatedue to hydrophobic interactions, so it is, in effect, an H+ carrier (Fedorenko et al. 2012).  Thermogenic Brown adipose tissue cells with increased UCP1 activity also have increased ATP sythase activity to allow maintenance of normal ATP levels (Guillen et al. 2013).

Eukaryota
Metazoa
UCP1 of Homo sapiens
*2.A.29.3.3









The uncoupling protein, UCP1 or PUMP (functions to relieve oxidative stress, and to allow efficient photosynthesis (Sweetlove et al., 2006).  In spome plants, it is activated in response to cold stress and may control reactive oxygen species (Valente et al. 2012).

Eukaryota
Viridiplantae
UCP1 of Arabidopsis thaliana
(O65623)
*2.A.29.3.4









Human UCP2; implicated in a variety of physiological and pathological processes including protection from oxidative stress, negative regulation of glucose sensing systems and the adaptation of fatty acid oxidation capacity to starvation. Not involved in thermogenesis as is UCP1 (Azzu and Brand, 2009). Leucine zipper EF hand-containing transmembrane protein 1 (LetM1; 2.A.97) and uncoupling proteins 2 and 3 (UCP2/3) contribute to two distinct mitochondrial Ca2+ uptake pathways (Waldeck-Weiermair et al., 2011).  Transports protons and chloride ions; activated by fatty acids and inhibited by purine nucleotides (Hoang et al. 2012).  Reduces mitochondrial Ca2+ uptake in response to intracellular Ca2+ release in pancreatic beta cells (Alam et al. 2012).  Arginine residues in TMS2 are important for chloride transport without affecting fatty acid-dependent proton transport (Hoang et al. 2015).

Eukaryota
Metazoa
UCP2 of Homo sapiens
*2.A.29.3.5









Human UCP3; implicated in a variety of physiological and pathological processes including protection from oxidative stress, negative regulation of glucose sensing systems and the adaptation of fatty acid oxidation capacity to starving. Not involved in thermogenesis as is UCP1 (Azzu and Brand, 2009). It also modulates the activity of the sarco/endoplasmic reticulum Ca2 -ATPase (SERCA) by decreasing mitochondrial ATP production (De Marchi et al., 2011). Leucine zipper EF hand-containing transmembrane protein 1 (LetM1; 2.A.97) and uncoupling proteins 2 and 3 (UCP2/3) contribute to two distinct mitochondrial Ca2 uptake pathways (Waldeck-Weiermair et al., 2011).  Transports protons and chloride ions; activated by fatty acids and inhibited by purine nucleotides (Hoang et al. 2012).

Eukaryota
Metazoa
UCP3 of Homo sapiens
*2.A.29.3.6









Uncouopling protein B, UCPB, of 268 aas and 5 TMSs, with TMS 5 deleted.  This protein can still function as an uncoupling protein (Ito et al. 2006).

Eukaryota
Viridiplantae
UCPB of Symplocarpus renifolius
*2.A.29.3.7









Uncoupling protein A (UCPA) of 303 aas and 6 TMSs.  Functions as an uncoupling protein, transporting protons across the mitochondrial inner membrane (Ito et al. 2006).

Eukaryota
Viridiplantae
UCPA of Symplocarpus renifolius (skunk cabbage)
*2.A.29.4.1









Phosphate carrier
Eukaryota
Metazoa
Phosphate carrier of Bos taurus
*2.A.29.4.2









Phosphate carrier protein (PiC); mitochondrial precursor (PTP) (SLC25A3).  Variants lead to a failure of inorganic phosphate (Pi) transport across the mitochondrial membrane, loss of oxidative phosphorylation, and phenotypically varied cases of skeletal myopathy and cardiomyopathy (Bhoj et al. 2015).

Eukaryota
Metazoa
SLC25A3 of Homo sapiens
*2.A.29.4.3









Phosphate carrier, Pic1: (PTP1; Mir1) (Hamel et al., 2004).  Also transports short chain (methane) phosphonates and medium chain (C12, C14 and C16) fatty acids which competitively inhibit phosphate transport (Engstová et al. 2001).

Eukaryota
Fungi
Pic1 of Saccharomyces cerevisiae (P23641)
*2.A.29.4.4









Phosphate carrier, Pic2: (PTP2; functionally equivalent paralogue of Pic1) (Hamel et al., 2004)
Eukaryota
Fungi
Pic2 of Saccharomyces cerevisiae (P40035)
*2.A.29.4.5









solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3

Eukaryota
Metazoa
Phosphate carrier of Mus musculus (Q8VEM8)
*2.A.29.4.6









Mitochondrial phosphate carrier-1, PiC1, AT5, PHT3;1 of 375 aas and 6 TMSs (Liu et al. 2017).

Eukaryota
Viridiplantae
PiC1 of Arabidopsis thaliana
*2.A.29.5.1









MRS3 iron (Fe2+) import carrier in the inner mitochondrial membrane; essential for erythroid iron utilization) (Mühlenhoff et al., 2003). Uptake is dependent on the pH gradient (Froschauer et al. 2009).
Eukaryota
Fungi
MRS3 of Saccharomyces cerevisiae
*2.A.29.5.2









MRS4 iron (Fe2+) import carrier in the inner mitochondrial membrane; essential for erythroid iron utilization) (Mühlenhoff et al., 2003). Uptake is dependent on the pH gradient (Froschauer et al. 2009).
Eukaryota
Fungi
MRS4 of Saccharomyces cerevisiae
*2.A.29.5.3









Mitochondrial iron transporter, mitoferrin (Shaw et al., 2006). Essential for erythroid iron utilization (Froschauer et al. 2009). Mitochondrial iron import regulation occurs through differential turnover of mitoferrin 1 and mitoferrin 2 (Paradkar et al., 2009)

Eukaryota
Metazoa
Mitoferrin of Brachydanio rerio (Q287T7)
*2.A.29.5.4









solute carrier family 25 (mitochondrial iron transporter), member 28, putative iron transporter; Mitoferrin-2

Eukaryota
Metazoa
Mitoferrin-2 of Mus musculus (Q8R0Z5)
*2.A.29.5.5









solute carrier family 25 (mitochondrial iron transporter), member 37, putative iron transporter, Mitoferrin-1

Eukaryota
Metazoa
Mitoferrin-1 of Mus musculus (Q920G8)
*2.A.29.5.6









Solute carrier family 25, member 38, SLC25A38; probably involved in heme biosynthesis by importing glycine and/or 5-aminolevulinate into mitochondria (Gutiérrez-Aguilar and Baines 2013).

Eukaryota
Metazoa
SLC25A38 of Homo sapiens
*2.A.29.5.7









Mitoferrin-1 (Mitochondrial iron transporter 1) (Mitochondrial solute carrier protein) (Solute carrier family 25 member 37)
Eukaryota
Metazoa
SLC25A37 of Homo sapiens
*2.A.29.5.8









Mitoferrin-2 (Mitochondrial RNA-splicing protein 3/4 homologue) (MRS3/4) (hMRS3/4) (Mitochondrial iron transporter 2) (Solute carrier family 25 member 28)

Eukaryota
Metazoa
SLC25A28 of Homo sapiens
*2.A.29.6.1









Peroxisomal carrier, PMP47. May be a transporter for several enzyme cofactors (based on similarity to human PMP34 (TC# 2.A.29.20.1)

Eukaryota
Fungi
PMP47 of Candida boidinii
*2.A.29.6.2









Peroxysomal/glyoxysomal PMP38 (PXN) of 331 aas. Mediates NAD import into peroxisomes. Favors NAD (in)/AMP(out) antiport, but can also catalyze unidirectional transport that might be essential under special conditions. Transports CoA, dephospho-CoA, acetyl-CoA, adenosine 3'',5''-diphosphate (PAP), NAD , AMP, ADP and NADH, but not ATP, GTP, GDP, NADPH, NADP or FAD. Required for peroxisomeal proliferation (Mano et al. 2011; Agrimi et al. 2012; Bernhardt et al. 2012).

Eukaryota
Viridiplantae
PMP38 of Arabidopsis thaliana
*2.A.29.7.1









Tricarboxylate carrier (exchanges a tricarboxylate (citrate, isocitrate, cis-aconitate) + H+ for another tricarboxylate + H+, a dicarboxylate (malate, succinate) or phosphoenolpyruvate).
Eukaryota
Metazoa
Citrate carrier of Rattus norvegicus
*2.A.29.7.2









Citrate/malate exchange carrier CIC (CTP); tricarboxylate carrier (citrate·H+/malate, PEP) (SLC25A1)

Eukaryota
Metazoa
SLC25A1 of Homo sapiens
*2.A.29.7.3









Citrate transport protein, CTP1. Catalyzes obligatory exchange of the dibasic form of tricarboxylates (citrate and isocitrate) for other tricarboxylates. Two citrate binding sites per monomer have been identified (Ma et al., 2007). Mutations in residues in internal or external pore regions can relax the specificity, converting CTP1 into a nonspecific anion carrier. The data is consistent with outward-facing, occluded, and inward-facing states.

Eukaryota
Fungi
CTP1 of Saccharomyces cerevisiae (P38152)
*2.A.29.7.4









The fruit fly citrate uptake carrier, CIC (expressed at all stages of development; same substrate as for other eukaryotic tricarboxylate transporters (Carrisi et al., 2008).
Eukaryota
Metazoa
CIC of Drosophila melanogaster (Q7KSQ0)
*2.A.29.7.5









The citrate carrier (CIC) (Madeo et al., 2009)

Eukaryota
Metazoa
CIC of Anguilla anguilla (Q1ENH3)
*2.A.29.8.1









Mitochondrial carnitine/acyl carnitine carrier (CAC)
Eukaryota
Metazoa
CAC of Rattus norvegicus
*2.A.29.8.2









Embryonic differentiation (DIF-1) protein
Eukaryota
Metazoa
DIF-1 of Caenorhabditis elegans
*2.A.29.8.3









Human mitochondrial carnitine/acyl carnitine carrier; carnitine/acyl carnitine translocase (CACT). Defects in CACT (SLC25A20) cause CACT deficiency [MIM212138] (autosomal recessive; lethal) (Indiveri et al., 2011).

Eukaryota
Metazoa
SLC25A20 of Homo sapiens
*2.A.29.8.4









Carnitine carrier, CRC1.  Exchanges carnitine for acetylcarnitine (Palmieri et al. 2006).

Eukaryota
Fungi
CRC1 of Saccharomyces cerevisiae (Q12289)
*2.A.29.8.5









The carnitine:acylcarnitine exchange translocase, CACL. CACL is similar in tissue distribution to that of CACT (TC# 2.A.29.8.3); both are expressed at a higher level in tissues using fatty acids as fuels, except the brain, where only CACL is expressed (Sekoguchi et al., 2003)
Eukaryota
Metazoa
CACL of Homo sapiens (Q8BL03)
*2.A.29.8.6









The mitochondrial basic amino acid transporter, in mBAC1 (transports the basic L-amino acids arginine, lysine, ornithine, and histidine in order of decreasing affinity; does not transport citrulline; expressed in stems, leaves, flowers, siliques, and seedlings; Km for arg=0.2mM) (Hoyos et al., 2003)
Eukaryota
Viridiplantae
mBAC1 of Arabidopsis thaliana (Q84UC7)
*2.A.29.8.7









solute carrier family 25, member 45
Eukaryota
Metazoa
SLC25A45 of Homo sapiens
*2.A.29.8.8









solute carrier family 25, member 48.  May be associated with Parkinson's disease (Gutiérrez-Aguilar and Baines 2013).

Eukaryota
Metazoa
SLC25A48 of Homo sapiens
*2.A.29.8.9









Mitochondrial carrier protein CACL (CACT-like) (Solute carrier family 25 member 29).  Transports basic amino acids (Porcelli et al. 2014).  It transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine. Carnitine and acylcarnitines were not transported by SLC25A29. This carrier catalyzes substantial uniport besides counter-exchange transport and exhibits a high transport affinity for arginine and lysine.  It is saturable and inhibited by mercurial compounds and other inhibitors of mitochondrial carriers to various degrees. The main physiological role of SLC25A29 is to import basic amino acids into mitochondria for mitochondrial protein synthesis and amino acid degradation (Porcelli et al. 2014).

Eukaryota
Metazoa
SLC25A29 of Homo sapiens
*2.A.29.8.10









Solute carrier family 25 member 47 (Hepatocellular carcinoma down-regulated mitochondrial carrier protein)
Eukaryota
Metazoa
SLC25A47 of Homo sapiens
*2.A.29.8.11









Carrier protein YMC2, mitochondrial
Eukaryota
Fungi
YMC2 of Saccharomyces cerevisiae
*2.A.29.8.12









Carrier protein YMC1, mitochondrial
Eukaryota
Fungi
YMC1 of Saccharomyces cerevisiae
*2.A.29.8.13









Basic amino acid carrier2, BAC2 of 296 aas and 6 TMSs.  This hyperosmotic stress-inducible porter transports proline in addition to basic amino acids (Toka et al. 2010).

Eukaryota
Viridiplantae
BAC2 of Arabidopsis thaliana
*2.A.29.8.14









Low-CO2-inducible chloroplast envelope protein, Ccp1, of 358 aas and 6 or 7 TMSs. Probabe HCO3- concentrating transporter (Atkinson et al. 2016).  May be present in mitochondria rather than chloroplasts.  Ccp2 (O24451) is 96% identical to Ccp1.

Eukaryota
Viridiplantae
Ccp1 of Chlamydomonas reinhardtii (Chlamydomonas smithii)
*2.A.29.9.1









Mitochondrial basic amino acid carrier (BAAC)
Eukaryota
Fungi
BAAC of Neurospora crassa
*2.A.29.9.2









Ornithine/arginine carrier, ORT1 or ARG11 (Palmieri et al., 1997).  Catalyzes H+:ornithine antiport for the export of ornithine from mitochondria (Palmieri et al. 2006).

Eukaryota
Fungi
ORT1 of Saccharomyces cerevisiae (Q12375)
*2.A.29.9.3









Uncharacterized protein of 416 aas and 6 - 7 TMSs, MITC1.

Eukaryota
Viridiplantae
MITC1 of Chlamydomonas reinhardtii (Chlamydomonas smithii)
*2.A.29.10.1









Flavin adenine dinucleotide (FAD) carrier (FADC; FLX1) (catalyzes FAD export from the mitochondrion) (Bafunno et al., 2004)
Eukaryota
Fungi
FLX1 of Saccharomyces cerevisiae
*2.A.29.10.2









Mitochondrial folate transporter, hMFT
Eukaryota
Metazoa
SLC25A32 of Homo sapiens
*2.A.29.10.3









Chloroplast folate/folate derivative transporter, AtFOLT1 (Bedhomme et al., 2005; Haferkamp and Schmitz-Esser 2012)

Eukaryota
Viridiplantae
AtFOLT1 of Arabidopsis thaliana (CAH65737)
*2.A.29.10.4









Mitochondrial pyrimidine nucleotide transporter, RIM2 (transports TTP (Km= 200 μM), UTP (Km= 400 μM) and CTP (Km= 440 μM). Catalyzes electroneutral TTP/TMP and TTP/TDP antiport. Deoxy pyrimidine nucleotides are also transported) (Marobbio et al., 2006). Pyrimidine trinucleotide transporter, RIM2 (transports TTP, CTP and UTP) (Todisco et al., 2006)
Eukaryota
Fungi
RIM2 of Saccharomyces cerevisiae
(P38127)
*2.A.29.10.5









The mitochondrial NAD+ uptake transporter, Ndt1 (also transports (d)AMP and (d)GMP but not α-NAD+, NADH, NADP+, or NADPH. Transport is saturable with an apparent Km of 0.38mM for NAD+). (70% identical to Ndt2 which also takes up NAD+). The main role of Ndt1p and Ndt2p is to import NAD+ into mitochondria by unidirectional transport or by exchange with intramitochondrially generated (d)AMP and (d)GMP (Todisco et al., 2006)
Eukaryota
Fungi
Ndt1 of Saccharomyces cerevisiae (P40556)
*2.A.29.10.6









solute carrier family 25 (pyrimidine nucleotide carrier ), member 36
Eukaryota
Metazoa
SLC25A36 of Homo sapiens
*2.A.29.10.7









solute carrier family 25 (pyrimidine nucleotide carrier), member 33
Eukaryota
Metazoa
SLC25A33 of Homo sapiens
*2.A.29.10.8









Mitochondrial nicotinamide adenine dinucleotide transporter 2, NDT2 (Mitochondrial NAD+ transporter 2) (Todisco et al. 2006).

Eukaryota
Fungi
YEA6 of Saccharomyces cerevisiae
*2.A.29.10.9









ADP/ATP-specific mitochondrial carrier (MC) in mitosomes (reduced mitochondria incapable of ATP synthesis) (Williams et al., 2008).
Eukaryota
Fungi
MC in Antonospora locustae (Q4VFZ9)
*2.A.29.10.10









Mitochondrial NAD /NADP carrier, NDT2; counter exchange substrates include ADP and AMP (Palmieri et al., 2009).

Eukaryota
Viridiplantae
NDT2 of Arabidopsis thaliana (Q8RWA5)
*2.A.29.10.11









Chloroplastic (plastidic) NAD /NADP carrier, NDT1; counter exchange substrates: ADP and AMP (Palmieri et al., 2009).

Eukaryota
Viridiplantae
NDT1 of Arabidopsis thaliana (O22261)
*2.A.29.11.1









The Plastid (Amyloplast) ADP-glucose transporter Brittle endosperm 1 (BT1) (Kirchberger et al., 2007).
Eukaryota
Viridiplantae
BT1 of Zea mays
*2.A.29.11.2









The Adenine nucleotide uniporter, BT1 (Leroch et al., 2005).
Eukaryota
Viridiplantae
BT1 of Solanum tuberosum (Q9ZNY4)
*2.A.29.11.3









The plastid ADP-glucose transporter, Nst1 (~90% identical to and probably orthologous with 2.A.29.11.1.) (Haferkamp, 2007).
Eukaryota
Viridiplantae
Nst1 of Hordeum vulgare (Q6E5A5)
*2.A.29.11.4









Adenine nucleotide (ATP, ADP) carrier, ANT1; BRITTLE-1.  Present in both mitochondria and plastids (Haferkamp and Schmitz-Esser 2012).

Eukaryota
Viridiplantae
ANT1 of Arabidopsis thaliana
*2.A.29.12.1









Grave’s disease carrier (GDC) protein.  Transports coenzyme A and/or a coenzyme A precursor (Vozza et al. 2016). SLC25A16 is the human orthologue.

Eukaryota
Metazoa
GDC of Bos taurus
*2.A.29.12.2









Mitochondrial exchange transporter for Coenzyme A and adenosine 3', 5'-diphosphate, SLC25A42 (also transports dephospho-Coenzyme A, and ADP; Fiermonte et al. 2009).

Eukaryota
Metazoa
SLC25A42 of Homo sapiens
*2.A.29.12.3









solute carrier family 25; mitochondrial carrier; Graves disease autoantigen, member 16.  It is a Coenzyme A transporter (Gutiérrez-Aguilar and Baines 2013).

Eukaryota
Metazoa
SLC25A16 of Homo sapiens
*2.A.29.12.4









Mitochondrial Coenzyme A carrier protein, LEU5 or Leu-5 (Gutiérrez-Aguilar and Baines 2013).

Eukaryota
Fungi
LEU5 of Saccharomyces cerevisiae
*2.A.29.12.5









Coenzyme A transporter of 331 aas (Zallot et al. 2013).

Eukaryota
Viridiplantae
Coenzyme A transporter of Arabidopsis thaliana
*2.A.29.12.6









Coenzyme A transporter of 325 aas (Zallot et al. 2013).

Eukaryota
Viridiplantae
Coenzyme A transporter of Arabidopsis thaliana
*2.A.29.12.7









Dephospho-coenzyme A (dPCoA) carrier, dPCoAC, of 365 aas and 6 TMSs. dPCoA is the best substrate, but ADP and dADP are also transported. Coenzyme A is not transported but is a strong competive inhibitor (Vozza et al. 2016).  Formerly called "alternative testis transcripts open reading frame A".

Eukaryota
Metazoa
dPCoAC of Drosophila melanogaster (Fruit fly)
*2.A.29.13.1









Succinate/fumarate antiporter, Sfc1, of 322 aas; essential for growth on ehtanol and acetate (Palmieri et al. 1997; Palmieri et al. 2006).

Eukaryota
Fungi
ACR1 of Saccharomyces cerevisiae
*2.A.29.14.1









Mitochondrial Ca2+-activated aspartate/glutamate antiporter carrier with Ca2+-binding EF-hand domain, Aralar
Eukaryota
Metazoa
SLC25A12 of Homo sapiens
*2.A.29.14.2









Mitochondrial Ca2+-activated aspartate/glutamate antiporter carrier with Ca2+-binding EF-hand domain, Citrin (defects in humans cause type II citrullinemia)
Eukaryota
Metazoa
SLC25A13 of Homo sapiens
*2.A.29.14.3









Mitochondrial glutamate carrier 1 (GC1); glutamate:H+ symporter 1 (SLC25A22). Plays a role in glucose-stimulated insulin secretion by β-cells (Casimir et al., 2009).  Also is responsible for migrating partial seizures in neonatal infancy (MPSI), a severe condition with few known etiologies (Poduri et al. 2013).

Eukaryota
Metazoa
SLC25A22 of Homo sapiens
*2.A.29.14.4









Yeast mitochondrial aspartate/glutamate antiporter, Agc1 (Cavero et al., 2003) (also catalyzes glutamate uniport and glutamate:proton symport (Palmieri et al. 2006). Comprised of 902 aas; has a 500 residue N-terminal hydrophilic domain as well as a C-terminal 100 residue hydrophilic domain. Both domains are uniquely found in members of the 2.A.29.14 subfamily.

Eukaryota
Fungi
Agc1 of Saccharomyces cerevisiae (NP_015346)
*2.A.29.14.5









solute carrier family 25 (glutamate carrier), member 18
Eukaryota
Metazoa
SLC25A18 of Homo sapiens
*2.A.29.14.6









solute carrier family 25, member 40.  This mitochondrial inner membrane transporter can be mutated (Y125C) to give hypertriglyceridemia (Rosenthal et al. 2013).  May also be involved in  primary Sjögren's syndrome (pSS), a prevalent and disabling form of fatigue (Norheim et al. 2014).

Eukaryota
Metazoa
SLC25A40 of Homo sapiens
*2.A.29.14.7









solute carrier family 25, member 44
Eukaryota
Metazoa
SLC25A44 of Homo sapiens
*2.A.29.14.8









Solute carrier family 25 member 39
Eukaryota
Metazoa
SLC25A39 of Homo sapiens
*2.A.29.14.9









MC family homologue of 327 aas and 6 TMSs

Eukaryota
Viridiplantae
MCP homologue of Ostreococcus lucimarinus
*2.A.29.14.10









Calcium-binding mitochondrial carrier protein Aralar1 of 690 aas.

Eukaryota
Fungi
Aralar1 of Verticillium alfalfae (Verticillium wilt of alfalfa) (Verticillium albo-atrum)
*2.A.29.15.1









Oxaloacetate/malonate/sulfate/thiosulfate transporter, OAC1
Eukaryota
Fungi
Oxaloacetate carrier (OAC1) of Saccharomyces cerevisiae
*2.A.29.15.2









solute carrier family 25, member 35
Eukaryota
Metazoa
SLC25A35 of Homo sapiens
*2.A.29.15.3









solute carrier family 25, member 34
Eukaryota
Metazoa
SLC25A34 of Homo sapiens
*2.A.29.16.1









Reported to be a deoxynucleotide (enzyme), the deoxynucleotide carrier (DNT) (all four dNDPs and less efficiently, all four dNTPs are transported, but not dNMPs, NMPs or nucleosides). It is also a thiamin pyrophosphate (TPP) transporter responsible for Amish lethal microencephaly brain development retardation (MCPHA) and α-ketoglutarate acidurua when defective (Arco and Satrústegui, 2005; Lindhurst et al., 2006; Iacopetta et al., 2010).

Eukaryota
Metazoa
SLC25A19 of Homo sapiens
*2.A.29.16.2









The thiamin pyrophosphate (TPP) transporter, Tpc1; catalyzes thiamin pyrophosphate/thiamin monophosphate excange (Palmieri et al. 2006).  Also transports pyrophosphate, ADP, ATP and other nucleotides (Iacopetta et al., 2010).

Eukaryota
Metazoa
Tpc1 of Drosophila melanogaster (Q7K0L7)
*2.A.29.16.3









Uncharacterized mitochondrial carrier C1604.04
Eukaryota
Fungi
SPBC1604.04 of Schizosaccharomyces pombe
*2.A.29.17.1









Peroxisomal ATP/ADP/AMP antiporter, Ant1 (Ypr128cp) (Palmieri et al. 2006).

Eukaryota
Fungi
Ant1 of Saccharomyces cerevisiae (AAB68270)
*2.A.29.18.1









Mitochondrial S-adenosylmethionine (SAM) carrier, Sam5p or PET8 (Marobbio et al., 2003).  Catalyzes the exchange of SAM for S-adenosylhomoserine as well as biotin and lipoate transport (Palmieri et al. 2006).

Eukaryota
Fungi
Sam5p of Saccharomyces cerevisiae (P38921)
*2.A.29.18.2









The plastid S-Adenosylmethionine importer, SAMT1 (regulates plastid biogenesis and plant development; catalyzes the counter-exchange of SAM with SAM and with S-adenosylhomocysteine) (Bouvier et al., 2006).  Also present in the mitochondrion (Haferkamp and Schmitz-Esser 2012).

Eukaryota
Viridiplantae
SAMT1 of Arabidopsis thaliana (Q94AG6)
*2.A.29.18.3









solute carrier family 25 (S-adenosylmethionine carrier), member 26
Eukaryota
Metazoa
SLC25A26 of Homo sapiens
*2.A.29.18.4









Uncharacterized protein of 369 aas and 6 TMSs

Eukaryota
Viridiplantae
UP of Chlamydomonas reinhardtii (Chlamydomonas smithii)
*2.A.29.19.1









Mitochondrial ornithine carrier 2 (ORC2 or OrnT2) (transports ornithine, citrulline, lysine, arginine, histidine); HHH syndrome (SLC25A2). Catalyzes ornithine:citrulline antiport and ornithine:H+ antiport (Tonazzi and Indiveri, 2011).

Eukaryota
Metazoa
SLC25A2 of Homo sapiens
*2.A.29.19.2









Mitochondrial ornithine transporter (ornithine/citrulline exchanger), SLC25A15 or Orc1. Catalyzes a vital step in the urea cycle, interconnecting the cytosolic and mitochondrial components for the cycle (Moraes and Reithmeier 2012).

Eukaryota
Metazoa
SLC25A15 of Homo sapiens
*2.A.29.20.1









Peroxisomal adenine nucleotide carrier, PMP34 (ANC; SLC25A17).  Probably specific for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extend for nicotinamide adenine dinucleotide (NAD+), adenosine diphosphate (ADP) and adenosine 3',5'-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD+ from the cytosol into the peroxisomal matrix by a counter-exchange mechanism. Inhibited by pyridoxal 5'-phosphate and bathophenanthroline in vitro (Visser et al. 2002; Agrimi et al. 2012).

Eukaryota
Metazoa
SLC25A17 of Homo sapiens
*2.A.29.20.2









Peroxisomal adenine nucleotide carrier 2, PNC2.  Transports ATP, ADP and NAD+ (Linka and Esser 2012).

Eukaryota
Viridiplantae
PNC2 of Arabidopsis thaliana
*2.A.29.20.3









Peroxisomal nucleotide (ATP, ADP, AMP) carrier-1, PNC1 (Haferkamp and Schmitz-Esser 2012).

Eukaryota
Viridiplantae
PNC1 of Arabidopsis thaliana
*2.A.29.21.1









Mitochondrial GTP/GDP exchange carrier (Ggc1) [also transports deoxyGTP and deoxyGDP as well as ITP and IDP but less well than GTP and GDP] [KM(GTP)=1 μM; KM(GDP)=5 μM]. Inhibited by pyridoxal-5-P, bathophenanthroline and tannic acid but not by inhibitors of the ATP-ADP carrier (Vozza et al., 2004). GGC appears to be intrinsically plastic with structural plasticity asymmetrically distributed among the three homologous domains (Sounier et al. 2015).

Eukaryota
Fungi
Ggc1 of Saccharomyces cerevisiae (NP_010083)
*2.A.29.22.1









Hydrogenosome ATP/ADP antiporter, HMP31 (Tjaden et al., 2004)
Eukaryota
Trichomonadida
HMP31 of Trichomonas gallinae (AAP30846)
*2.A.29.22.2









The Mitosome (crypton) ADP/ATP carrier (Chan et al., 2005)

Eukaryota
Entamoeba
Mitosome ADP/ATP carrier of Entamoeba histolytica (AAK69775)
*2.A.29.23.1









Mitochondrial ATP-Mg2+/inorganic phosphate antiporter [3 isoforms in humans with 3 EF-hand CA2+ binding motifs in their N-terminal domain: Q6KCM7, Q9BV35, and Q6NUK1] (Fiermonte et al., 2004)
Eukaryota
Metazoa
SLC25A25 of Homo sapiens
*2.A.29.23.2









Mg2+-ATP/Pi carrier, Sal1 (Ca2+ binding carrier, CMC1; supressor of AAC2 lethality (EF hand Ca2+ binding motif at N-terminus). ADP:ATP carrier 2 (Kucejova et al., 2008; Traba et al., 2008)
Eukaryota
Fungi
Sal1 of Saccharomyces cerevisiae (P48233)
*2.A.29.23.3









Chloroplast thylakoid ATP/ADP antiporter, TAAC (Thuswaldner et al., 2007; Haferkamp et al., 2011).  Also transports 3'-phosphoadenosine 5'-phosphosulfate (PAPS), made in the mitochondria and exported to the cytoplasm where it is involved in several aspects of sulfur metabolism, including the biosynthesis of thiols, glucosinolates, and phytosulfokines, and therefore also named PAPST1 (Gigolashvili et al. 2012).  Expression of the PAPST1 gene is regulated by the same MYB transcription factors that also regulate the biosynthesis of sulfated secondary metabolites, glucosinolates.

Eukaryota
Viridiplantae
TAAC of Arabidopsis thaliana (Q9M024)
*2.A.29.23.4









The mitochondrial adenine nucleotide transporter, ADNT1 (At4g01100) (prefers AMP and ADP to ATP; not inhibited by bongkrekate or carboxyatractyloside; loss yields reduced root growth and respiration) (Palmieri et al., 2008b).
Eukaryota
Viridiplantae
ADNT1 of Arabidopsis thaliana (O04619)
*2.A.29.23.5









solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
Eukaryota
Metazoa
SLC25A23 of Homo sapiens
*2.A.29.23.6









solute carrier family 25, member 41
Eukaryota
Metazoa
SLC25A41 of Homo sapiens
*2.A.29.23.7









solute carrier family 25, member 43.  May play a role in Paget's bone disease (Gutiérrez-Aguilar and Baines 2013).  Also regulates cell cycle progression and proliferation through a putative mitochondrial checkpoint (Gabrielson et al. 2015).

Eukaryota
Metazoa
SLC25A43 of Homo sapiens
*2.A.29.23.8









Calcium-binding mitochondrial carrier protein SCaMC-1 (Mitochondrial ATP-Mg/Pi carrier protein 1; Mitochondrial Ca2+-dependent solute carrier protein 1; Small calcium-binding mitochondrial carrier protein 1; Solute carrier family 25 member 24).  The crystal structure of the N-terminal Ca2+-binding domain has been determined and shown to undergo a large conformational change when Ca2+ binds (Yang et al. 2014).

Eukaryota
Metazoa
SLC25A24 of Homo sapiens
*2.A.29.23.9









Mitochondrial transporter for 3′-phospho-adenosine 5′-phosphosulfate and adenosine 5′-phosphosulfate (APS), YPR011c.  Sulfate and phosphate are also transported using an antiport mechanism (Todisco et al. 2014).  Inhibited by bongkrekic acid.  Deletion mutants are thermal sensitive and have less methionine and glutathione.  The gene is induced by thermal stress conditions (Todisco et al. 2014).

Eukaryota
Fungi
YPR011c of Saccharomyces cerevisiae
*2.A.29.24.1









Brain mitochondrial carrier protein 1, BMCP1 (participates in mitochondrial proton leak) (also called uncoupling protein-5 (UCP5)) (Sanchis et al., 1998).  Transports protons and chloride ions; activated by fatty acids and inhibited by purine nucleotides similarly to UCP1-3 (Hoang et al. 2012); H+ transport may be activated while Cl- transport may be inhibited by faty acids (Hoang et al. 2015). 

Eukaryota
Metazoa
SLC25A14 of Homo sapiens
*2.A.29.24.2









Kidney mitochondrial carrier protein, KMCP1 (Haguenauer et al., 2005)
Eukaryota
Metazoa
KMCP1 of Mus musculus (NP_080508)
*2.A.29.24.3









solute carrier family 25, member 27; UCP4.  Transports protons and chloride ions; activated by fatty acids and inhibited by purine nucleotides similarly to UCP1-3 (Hoang et al. 2012).  H+ transport may be activated while Cl- transport may be inhibited by fatty acids (Hoang et al. 2015).

Eukaryota
Metazoa
SLC25A27 of Homo sapiens
*2.A.29.24.4









solute carrier family 25, member 30; Kidney MCP1

Eukaryota
Metazoa
SLC25A30 of Homo sapiens
*2.A.29.25.1









The mitochondrial presenilin-associated protein (PSAP; MTCH1) binds to the PDZ domain (a QFYI motif) C-terminus of presenilin. It contains 2 solcar repeats and is 389 aas long. It is most similar to 2.A.29.23.1 and 2.A.29.12.1. There are 2 human isoforms, mitochondrial carrier homologues, MTCH1 and MTCH2, possibly involved in apoptosis (Xu et al., 1999, 2002). Its transport function is unknown (Xu et al., 1999, 2002).  Surprisingly, this protein has been reported to be targetted to the outer mitochonrdial membrane (Gutiérrez-Aguilar and Baines 2013). Two proapoptotic PSAP isoforms generated by alternative splicing differ in the length of a hydrophilic loop located between two predicted transmembrane domains. Both isoforms are expressed in human and rat tissues. PSAP probably contains multiple mitochondrial targeting motifs dispersed along the protein (Lamarca et al. 2007).

Eukaryota
Metazoa
MTCH1 of Homo sapiens (Q9NZJ7)
*2.A.29.25.2









The mitochondrial carrier homologue-2 (MTCH2). Binds the BH3-interacting domain death agonist, BID. Regulated (induced) by the hepatocyte growth factor receptor, HGF/SF or Met. It has been proposed that its transport function has been lost (Robinson et al., 2012). Surprisingly, this protein has been reported to be targetted to the outer mitochondrial membrane (Gutiérrez-Aguilar and Baines, 2013).

Eukaryota
Metazoa
MTCH2 of Homo sapiens (Q9Y6C9)
*2.A.29.26.1









Viral mitochondrial carrier-like protein, L276 (VMC) for dATP and dTTP (237 aas) (Monné et al., 2007).

Viruses
Mimiviridae
VMC of Mimiviridae mimivirus (Q5UPV8)
*2.A.29.27.1









The ATP exchanger/symporter, LcnP (secreted via the bacterial Dot/Icm type IV secretion system into macrophages, and assembled in the mitochondrial inner membrane (Dolezal et al., 2012)).

Bacteria
Proteobacteria
LcnP of Legionella pneumophila (Q5WSP6)
*2.A.29.28.1









The thiamin pyrophosphate (TPP) carrier, TPC1 (Marobbio et al., 2002).
Eukaryota
Fungi
TPC1 of Saccharomyces cerevisiae (NP_011610)
*2.A.29.29.1









The citrate/oxoglutarate carrier, Yhm2 (Castegna et al., 2010; Mayor et al., 1997). Ymh2 also transports oxaloacetate, succinate, and fumarate, but not malate or isocitrate. It may function in antioxidation (Castegna et al., 2010).

Eukaryota
Fungi
Yhm2 of Saccharomyces cerevisiae (Q04013)
*2.A.29.30.1









The human mitochondrial carrier (418aas; 6 TMSs) of unknown function (SLC25A46).  May play a role in atopic dermatitis (Gutiérrez-Aguilar and Baines 2013).

Eukaryota
Metazoa
SLC25A46 of Homo sapiens
*2.A.29.31.1









Sequence-divergent mitochondrial carrier of 394 aas and 6 TMSs, MCP14.  The T. brucei MCP14 appears to be involved in energy metabolism but it also mediates drug action and is required for cell growth and viability (de Macêdo et al. 2015).  TbMCP14 belongs to a trypanosomatid-specific clade of the mitochondrial carrier family.

Eukaryota
Kinetoplastida
MCP14 of Trypanosoma cruzi
*2.A.29.31.2









MCP14 orthologue of 447 aas and 6 TMSs

Eukaryota
Kinetoplastida
MCP14 of Leishmania major
*2.A.29.31.3









MCP14 paralogue of 361 aas and 6 TMSs

Eukaryota
Kinetoplastida
MCP14 of Trypanosoma cruzi
*2.A.29.31.4









MCP14 homologue of 338 aas and 6 TMSs.

Eukaryota
Kinetoplastida
MCP14 homologue of Strigomonas culicis