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2.A.29.1.1
Mitochondrial ATP/ADP antiporter 2 (SLC25A5; ANT2) of 298 aas and 6 TMSs; it facilitates exchange of ADP and ATP between the cytosol and mitochondrial matrix (inhibited by carboxyatractyloside and bongkrekate) (Clémençon et al. 2013).  Modification of lysyl residues with fluorescamine induces Ca2+ permeability (Buelna-Chontal et al. 2014). Ca2+ induces oxidative stress, which increases lipid peroxidation and ROS generation, collapses the transmembrane potential and releases cytochrome c (Correa et al. 2018). Thus, pore opening in the inner mitochondrial membrane results from the binding of Ca2+ to the adenine nucleotide translocase. It is methylated by FAM173A, a mitochondrial lysine-specific methyltransferase that targets ANTs 2 and 3, and affects mitochondrial respiration (MaƂecki et al. 2019).

Accession Number:P05141
Protein Name:ADP/ATP translocase 2
Length:298
Molecular Weight:32895.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate ATP, ADP

Cross database links:

DIP-33873NDIP-33873N
Genevestigator: P05141 P05141 P05141
eggNOG: prNOG18664 NOG238123 NOG238123
RefSeq: NP_001143.2   
Entrez Gene ID: 292   
Pfam: PF00153   
Drugbank: Drugbank Link   
OMIM: 300150  gene
KEGG: hsa:292    hsa:292    hsa:292   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005743 C:mitochondrial inner membrane
GO:0042645 C:mitochondrial nucleoid
GO:0015207 F:adenine transmembrane transporter activity
GO:0005515 F:protein binding
GO:0044419 P:interspecies interaction between organisms
GO:0055085 P:transmembrane transport
GO:0071817 C:MMXD complex
GO:0007059 P:chromosome segregation
GO:0006112 P:energy reserve metabolic process
GO:0050796 P:regulation of insulin secretion
GO:0044281 P:small molecule metabolic process
GO:0016032 P:viral reproduction

References (33)

[1] “The human fibroblast adenine nucleotide translocator gene. Molecular cloning and sequence.”  Ku D.-H.et.al.   2168878
[2] “Molecular cloning of a cDNA for a human ADP/ATP carrier which is growth-regulated.”  Battini R.et.al.   3031073
[3] “Ordered shotgun sequencing of a 135 kb Xq25 YAC containing ANT2 and four possible genes, including three confirmed by EST matches.”  Chen C.N.et.al.   8918809
[4] “The DNA sequence of the human X chromosome.”  Ross M.T.et.al.   15772651
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver.”  Houldsworth J.et.al.   2829183
[7] “Mitochondrial membrane permeabilization by HIV-1 Vpr.”  Deniaud A.et.al.   16120388
[8] “Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.”  Rikova K.et.al.   18083107
[9] “Lysine acetylation targets protein complexes and co-regulates major cellular functions.”  Choudhary C.et.al.   19608861
[10] “The human fibroblast adenine nucleotide translocator gene. Molecular cloning and sequence.”  Ku D.-H.et.al.   2168878
[11] “Molecular cloning of a cDNA for a human ADP/ATP carrier which is growth-regulated.”  Battini R.et.al.   3031073
[12] “Ordered shotgun sequencing of a 135 kb Xq25 YAC containing ANT2 and four possible genes, including three confirmed by EST matches.”  Chen C.N.et.al.   8918809
[13] “The DNA sequence of the human X chromosome.”  Ross M.T.et.al.   15772651
[14] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[15] “Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver.”  Houldsworth J.et.al.   2829183
[16] “Mitochondrial membrane permeabilization by HIV-1 Vpr.”  Deniaud A.et.al.   16120388
[17] “Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.”  Rikova K.et.al.   18083107
[18] “Lysine acetylation targets protein complexes and co-regulates major cellular functions.”  Choudhary C.et.al.   19608861
[19] “MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation.”  Ito S.et.al.   20797633
[20] “Initial characterization of the human central proteome.”  Burkard T.R.et.al.   21269460
[21] “The first identification of lysine malonylation substrates and its regulatory enzyme.”  Peng C.et.al.   21908771
[22] “The human fibroblast adenine nucleotide translocator gene. Molecular cloning and sequence.”  Ku D.-H.et.al.   2168878
[23] “Molecular cloning of a cDNA for a human ADP/ATP carrier which is growth-regulated.”  Battini R.et.al.   3031073
[24] “Ordered shotgun sequencing of a 135 kb Xq25 YAC containing ANT2 and four possible genes, including three confirmed by EST matches.”  Chen C.N.et.al.   8918809
[25] “The DNA sequence of the human X chromosome.”  Ross M.T.et.al.   15772651
[26] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[27] “Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver.”  Houldsworth J.et.al.   2829183
[28] “Mitochondrial membrane permeabilization by HIV-1 Vpr.”  Deniaud A.et.al.   16120388
[29] “Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.”  Rikova K.et.al.   18083107
[30] “Lysine acetylation targets protein complexes and co-regulates major cellular functions.”  Choudhary C.et.al.   19608861
[31] “MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation.”  Ito S.et.al.   20797633
[32] “Initial characterization of the human central proteome.”  Burkard T.R.et.al.   21269460
[33] “The first identification of lysine malonylation substrates and its regulatory enzyme.”  Peng C.et.al.   21908771

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FASTA formatted sequence
1:	MTDAAVSFAK DFLAGGVAAA ISKTAVAPIE RVKLLLQVQH ASKQITADKQ YKGIIDCVVR 
61:	IPKEQGVLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL GGVDKRTQFW RYFAGNLASG 
121:	GAAGATSLCF VYPLDFARTR LAADVGKAGA EREFRGLGDC LVKIYKSDGI KGLYQGFNVS 
181:	VQGIIIYRAA YFGIYDTAKG MLPDPKNTHI VISWMIAQTV TAVAGLTSYP FDTVRRRMMM 
241:	QSGRKGTDIM YTGTLDCWRK IARDEGGKAF FKGAWSNVLR GMGGAFVLVL YDEIKKYT