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2.A.29.18.6
Inner membrane mitochondrial magnesium exporter, Mme1 of 347 aas and 6 (- 8?) TMSs. Deletion of MME1 significantly increased steady-state mitochondrial Mg2+ concentrations, while overexpression decreased them. Measurements of Mg2+ exit from proteoliposomes reconstituted with purified Mme1 provided definite evidence that Mme1 is an Mg2+ exporter (Cui et al. 2015). The G-M-N motif determines ion selectivity, probably together with the negatively charged loop at the entrance of the channel, thereby forming the selectivity filter (Sponder et al. 2013).

Accession Number:Q03829
Protein Name:Uncharacterized mitochondrial carrier YMR166C
Length:368
Molecular Weight:40992.00
Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate

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FASTA formatted sequence
1:	MNSWNLSSSI PIIHTPHDHP PTSEGTPDQP NNNRKDDKLH KKRGDSDEDL SPIWHCVVSG 
61:	GIGGKIGDSA MHSLDTVKTR QQGAPNVKKY RNMISAYRTI WLEEGVRRGL YGGYMAAMLG 
121:	SFPSAAIFFG TYEYTKRTMI EDWQINDTIT HLSAGFLGDF ISSFVYVPSE VLKTRLQLQG 
181:	RFNNPFFQSG YNYSNLRNAI KTVIKEEGFR SLFFGYKATL ARDLPFSALQ FAFYEKFRQL 
241:	AFKIEQKDGR DGELSIPNEI LTGACAGGLA GIITTPMDVV KTRVQTQQPP SQSNKSYSVT 
301:	HPHVTNGRPA ALSNSISLSL RTVYQSEGVL GFFSGVGPRF VWTSVQSSIM LLLYQMTLRG 
361:	LSNAFPTD