TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.3.10.8
Tryptophan permease, Tat2. Regulated via endocytosis by ATP-binding Cassette Transporters, Pdr5 (3.A.1.205.1) and Yor1 (3.A.208.3) as well as a seven-transmembrane protein, RSB1 (9.A.27.1.2) (Johnson et al., 2010).  Residues involved in binding and catalysis have been identified (Kanda and Abe 2013).  residues and regions important for proper folding and ER retention have been identified (Mochizuki et al. 2015).

Accession Number:P38967
Protein Name:Tat2 aka TAP2 aka SCM2 aka LTG3 aka SAB2 aka YOL020W
Length:592
Molecular Weight:65404.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate tryptophan

Cross database links:

Genevestigator: P38967
eggNOG: fuNOG08245
HEGENOM: HBG492579
DIP: DIP-1782N
RefSeq: NP_014622.1   
Entrez Gene ID: 854139   
Pfam: PF00324   
KEGG: sce:YOL020W   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0003824 F:catalytic activity
GO:0005300 F:high-affinity tryptophan transmembrane tran...
GO:0005515 F:protein binding
GO:0055085 P:transmembrane transport
GO:0015827 P:tryptophan transport

References (7)

[1] “Two FK506 resistance-conferring genes in Saccharomyces cerevisiae, TAT1 and TAT2, encode amino acid permeases mediating tyrosine and tryptophan uptake.”  Schmidt A.et.al.   7523855
[2] “SCM2, a tryptophan permease in Saccharomyces cerevisiae, is important for cell growth.”  Chen X.H.et.al.   8058037
[3] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.”  Dujon B.et.al.   9169874
[4] “Cysteine uptake by Saccharomyces cerevisiae is accomplished by multiple permeases.”  During-Olsen L.et.al.   10467005
[5] “Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae.”  Regenberg B.et.al.   10654085
[6] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[7] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MTEDFISSVK RSNEELKERK SNFGFVEYKS KQLTSSSSHN SNSSHHDDDN QHGKRNIFQR 
61:	CVDSFKSPLD GSFDTSNLKR TLKPRHLIMI AIGGSIGTGL FVGSGKAIAE GGPLGVVIGW 
121:	AIAGSQIIGT IHGLGEITVR FPVVGAFANY GTRFLDPSIS FVVSTIYVLQ WFFVLPLEII 
181:	AAAMTVQYWN SSIDPVIWVA IFYAVIVSIN LFGVRGFGEA EFAFSTIKAI TVCGFIILCV 
241:	VLICGGGPDH EFIGAKYWHD PGCLANGFPG VLSVLVVASY SLGGIEMTCL ASGETDPKGL 
301:	PSAIKQVFWR ILFFFLISLT LVGFLVPYTN QNLLGGSSVD NSPFVIAIKL HHIKALPSIV 
361:	NAVILISVLS VGNSCIFASS RTLCSMAHQG LIPWWFGYID RAGRPLVGIM ANSLFGLLAF 
421:	LVKSGSMSEV FNWLMAIAGL ATCIVWLSIN LSHIRFRLAM KAQGKSLDEL EFVSAVGIWG 
481:	SAYSALINCL ILIAQFYCSL WPIGGWTSGK ERAKIFFQNY LCALIMLFIF IVHKIYYKCQ 
541:	TGKWWGVKAL KDIDLETDRK DIDIEIVKQE IAEKKMYLDS RPWYVRQFHF WC