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2.A.3.10.9
Val/Tyr/Trp permease

Accession Number:P38085
Protein Name:Val1 aka Tat1 aka VAP1 aka TAP1aka YBR069C aka YBR0710
Length:619
Molecular Weight:68758.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Valine, tyrosine, tryptophan

Cross database links:

Genevestigator: P38085
eggNOG: fuNOG13848
HEGENOM: HBG492579
DIP: DIP-4912N
RefSeq: NP_009625.1   
Entrez Gene ID: 852361   
Pfam: PF00324   
KEGG: sce:YBR069C   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0022893 F:low-affinity tryptophan transmembrane trans...
GO:0005515 F:protein binding
GO:0055085 P:transmembrane transport
GO:0015827 P:tryptophan transport
GO:0015828 P:tyrosine transport

References (13)

[1] “Two FK506 resistance-conferring genes in Saccharomyces cerevisiae, TAT1 and TAT2, encode amino acid permeases mediating tyrosine and tryptophan uptake.”  Schmidt A.et.al.   7523855
[2] “Complete DNA sequence of yeast chromosome II.”  Feldmann H.et.al.   7813418
[3] “Sequence analysis of a 31 kb DNA fragment from the right arm of Saccharomyces cerevisiae chromosome II.”  van der Aart Q.J.M.et.al.   7985423
[4] “Cysteine uptake by Saccharomyces cerevisiae is accomplished by multiple permeases.”  During-Olsen L.et.al.   10467005
[5] “Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae.”  Ficarro S.B.et.al.   11875433
[6] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[7] “A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery.”  Hitchcock A.L.et.al.   14557538
[8] “Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.”  Gruhler A.et.al.   15665377
[9] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258
[10] “Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.”  Li X.et.al.   17330950
[11] “Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.”  Chi A.et.al.   17287358
[12] “Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.”  Smolka M.B.et.al.   17563356
[13] “A multidimensional chromatography technology for in-depth phosphoproteome analysis.”  Albuquerque C.P.et.al.   18407956

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDDSVSFIAK EASPAQYSHS LHERTHSEKQ KRDFTITEKQ DEVSGQTAEP RRTDSKSILQ 
61:	RKCKEFFDSF KRQLPPDRNS ELESQEKNNL TKSIKSRHLV MISLGTGIGT GLLVGNGQVL 
121:	GTAGPAGLVL GYGIASIMLY CIIQAAGELG LCYAGLTGNY TRYPSILVDP SLGFAVSVVY 
181:	TIQWLTVLPL QLVTAAMTVK YWTSVNADIF VAVVFVFVII INLFGSRGYA EAEFIFNSCK 
241:	ILMVIGFVIL AIIINCGGAG DRRYIGAEYW HNPGPFAHGF KGVCTVFCYA AFSYGGIEVL 
301:	LLSAAEQENP TKSIPNACKK VVYRILLIYM LTTILVCFLV PYNSDELLGS SDSSGSHASP 
361:	FVIAVASHGV KVVPHFINAV ILISVISVAN SSLYSGPRLL LSLAEQGVLP KCLAYVDRNG 
421:	RPLLCFFVSL VFGCIGFVAT SDAEEQVFTW LLAISSLSQL FIWMSMSLSH IRFRDAMAKQ 
481:	GRSMNEVGYK AQTGYWGSWL AVLIAIFFLV CQFWVAIAPV NEHGKLNVKV FFQNYLAMPI 
541:	VLFAYFGHKI YFKSWSFWIP AEKIDLDSHR NIFVSPSLTE IDKVDDNDDL KEYENSESSE 
601:	NPNSSRSRKF FKRMTNFWC