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2.A.3.13.1
The hydrophobic amino acid efflux transporter, YjeH (exports L-methionine and other neutral, hydrophobic amino acids such as Leu, Ile and Val; R. Figge, personal communication; Liu et al. 2015).

Accession Number:P39277
Protein Name:Inner membrane protein yjeH aka YjeH
Length:418
Molecular Weight:44778.00
Species:Escherichia coli [83333]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Methionine

Cross database links:

Genevestigator: P39277
EchoBASE: EB2363
EcoGene: EG12470
eggNOG: COG0531
HEGENOM: HBG298610
DIP: DIP-12573N
RefSeq: AP_004642.1    NP_418565.1   
Entrez Gene ID: 948656   
Pfam: PF00324   
BioCyc: EcoCyc:B4141-MONOMER    ECOL168927:B4141-MONOMER   
KEGG: ecj:JW4101    eco:b4141   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015171 F:amino acid transmembrane transporter activity
GO:0006865 P:amino acid transport
GO:0055085 P:transmembrane transport

References (4)

[1] “Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes.”  Burland V.D.et.al.   7610040
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSGLKQELGL AQGIGLLSTS LLGTGVFAVP ALAALVAGNN SLWAWPVLII LVFPIAIVFA 
61:	ILGRHYPSAG GVAHFVGMAF GSRLERVTGW LFLSVIPVGL PAALQIAAGF GQAMFGWHSW 
121:	QLLLAELGTL ALVWYIGTRG ASSSANLQTV IAGLIVALIV AIWWAGDIKP ANIPFPAPGN 
181:	IELTGLFAAL SVMFWCFVGL EAFAHLASEF KNPERDFPRA LMIGLLLAGL VYWGCTVVVL 
241:	HFDAYGEKMA AAASLPKIVV QLFGVGALWI ACVIGYLACF ASLNIYIQSF ARLVWSQAQH 
301:	NPDHYLARLS SRHIPNNALN AVLGCCVVST LVIHALEINL DALIIYANGI FIMIYLLCML 
361:	AGCKLLQGRY RLLAVVGGLL CVLLLAMVGW KSLYALIMLA GLWLLLPKRK TPENGITT