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2.A.3.2.3
Arginine:ornithine antiporter

Accession Number:P18275
Protein Name:ArcD aka PA5170
Length:482
Molecular Weight:52027.00
Species:Pseudomonas aeruginosa [287]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Arginine, Ornithine

Cross database links:

HEGENOM: HBG586921
RefSeq: NP_253857.1   
Entrez Gene ID: 881800   
Pfam: PF00324   
BioCyc: PAER208964:PA5170-MONOMER   
KEGG: pae:PA5170   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015171 F:amino acid transmembrane transporter activity
GO:0015297 F:antiporter activity
GO:0006865 P:amino acid transport
GO:0055085 P:transmembrane transport

References (3)

[1] “The arc operon for anaerobic arginine catabolism in Pseudomonas aeruginosa contains an additional gene, arcD, encoding a membrane protein.”  Luethi E.et.al.   2158926
[2] “Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.”  Stover C.K.et.al.   10984043
[3] “arcD, the first gene of the arc operon for anaerobic arginine catabolism in Pseudomonas aeruginosa, encodes an arginine-ornithine exchanger.”  Verhoogt H.J.et.al.   1311296

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSQESSQKLR LGALTALVVG SMIGGGIFSL PQNMAASADV GAVLIGWAIT AVGMLTLAFV 
61:	FQTLANRKPE LDGGVYAYAK AGFGDYMGFS SAWGYWISAW LGNVGYFVLL FSTLGYFFPI 
121:	FGKGDTVAAI VCASVLLWAL HFLVLRGIKE AAFINTVTTV AKVVPLFLFI LICLFAFKLD 
181:	IFTADIWGKS NPDLGSVMNQ VRNMMLVTVW VFIGIEGASI FSSRAEKRSD VGKATVIGFI 
241:	TVLLLLVLVN VLSMGVMTQP ELAKLQNPSM ALVLEHVVGH WGAVLISVGL LISLLGALLS 
301:	WVLLCAEIMF AAAKDHTMPE FLRRENANQV PANALWLTNI CVQVFLVVVF FTSGDPDGMD 
361:	PYTKMLLLAT SMILIPYFWS AAYGLLLTLK GETYENDARE RSKDLVIAGI AVAYAVWLLY 
421:	AGGLKYLLLS ALLYAPGAIL FAKAKHEVGQ PIFTGIEKLI FAAVVIGALV AAYGLYDGFL 
481:	TL