TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.3.2.4
Lysine permease

Accession Number:P35865
Protein Name:LysI aka CGL0968
Length:501
Molecular Weight:53630.00
Species:Corynebacterium glutamicum (Brevibacterium flavum) [1718]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate lysine

Cross database links:

HEGENOM: HBG586921
RefSeq: NP_600195.1    YP_225261.1   
Entrez Gene ID: 1018958    3343706   
Pfam: PF00324   
BioCyc: CGLU196627:CG1105-MONOMER   
KEGG: cgb:cg1105    cgl:NCgl0929   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015171 F:amino acid transmembrane transporter activity
GO:0006865 P:amino acid transport
GO:0055085 P:transmembrane transport

References (2)

[1] “Molecular analysis of the Corynebacterium glutamicum lysl gene involved in lysine uptake.”  Seep-Feldhaus A.H.et.al.   1667221
[2] “The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins.”  Kalinowski J.et.al.   12948626

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MNTQSDSAGS QGAAATSRTV SIRTLIALII GSTVGAGIFS IPQNIGSVAG PGAMLIGWLI 
61:	AGVGMLSVAF VFHVLARRKP HLDSGVYAYA RVGLGDYVGF SSAWGYWLGS VIAQVGYATL 
121:	FFSTLGHYVP LFSQDHPFVS ALAVSALTWL VFGVVSRGIS QAAFLTTVTT VAKILPLLCF 
181:	IILVAFLGFS WEKFTVDLWA RDGGVGSIFD QVRGIMVYTV WVFIGIEGAS VYSRQARSRS 
241:	DVSRATVIGF VAVLLLLVSI SSLSFGVLTQ QELAALPDNS MASVLEAVVG PWGAALISLG 
301:	LCLSVLGAYV SWQMLCAEPL ALMAMDGLIP SKIGAINSRG AAWMAQLIST IVIQIFIIIF 
361:	FLNETTYVSM VQLATNLYLV PYLFSAFYLV MLATRGKGIT HPHAGTRFDD SGPEISRREN 
421:	RKHLIVGLVA TVYSVWLFYA AEPQFVLFGA MAMLPGLIPY VWTRIYRGEQ VFNRFEIGVV 
481:	VVLVVAASAG VIGLVNGSLS L