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2.A.3.3.1
System Y+ high affinity basic amino acid transporter (CAT1) (ecotropic retrovival leukemia virus receptor (ERR)) (transports arginine, lysine and ornithine; Na+-independent)

Accession Number:Q09143
Protein Name:CTR1 aka CAT1 aka ERR aka SLC7A1 aka ATRC1 aka REC-1
Length:622
Molecular Weight:67092.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Arginine, lysine, Ornithine

Cross database links:

Genevestigator: Q09143
eggNOG: roNOG13208
HEGENOM: HBG727793
RefSeq: NP_031539.3   
Entrez Gene ID: 11987   
Pfam: PF00324   
KEGG: mmu:11987   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015181 F:arginine transmembrane transporter activity
GO:0004872 F:receptor activity
GO:0015809 P:arginine transport
GO:0055085 P:transmembrane transport

References (2)

[1] “A putative murine ecotropic retrovirus receptor gene encodes a multiple membrane-spanning protein and confers susceptibility to virus infection.”  Albritton L.M.et.al.   2541919
[2] “Transport of cationic amino acids by the mouse ecotropic retrovirus receptor.”  Kim J.W.et.al.   1652100

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGCKNLLGLG QQMLRRKVVD CSREESRLSR CLNTYDLVAL GVGSTLGAGV YVLAGAVARE 
61:	NAGPAIVISF LIAALASVLA GLCYGEFGAR VPKTGSAYLY SYVTVGELWA FITGWNLILS 
121:	YIIGTSSVAR AWSATFDELI GKPIGEFSRQ HMALNAPGVL AQTPDIFAVI IIIILTGLLT 
181:	LGVKESAMVN KIFTCINVLV LCFIVVSGFV KGSIKNWQLT EKNFSCNNND TNVKYGEGGF 
241:	MPFGFSGVLS GAATCFYAFV GFDCIATTGE EVKNPQKAIP VGIVASLLIC FIAYFGVSAA 
301:	LTLMMPYFCL DIDSPLPGAF KHQGWEEAKY AVAIGSLCAL STSLLGSMFP MPRVIYAMAE 
361:	DGLLFKFLAK INNRTKTPVI ATVTSGAIAA VMAFLFELKD LVDLMSIGTL LAYSLVAACV 
421:	LVLRYQPEQP NLVYQMARTT EELDRVDQNE LVSASESQTG FLPVAEKFSL KSILSPKNVE 
481:	PSKFSGLIVN ISAGLLAALI ITVCIVAVLG REALAEGTLW AVFVMTGSVL LCMLVTGIIW 
541:	RQPESKTKLS FKVPFVPVLP VLSIFVNIYL MMQLDQGTWV RFAVWMLIGF TIYFGYGIWH 
601:	SEEASLAAGQ AKTPDSNLDQ CK