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2.A.3.3.10
Cationic amino acid transporter 3 (CAT-3) (CAT3) (Cationic amino acid transporter y+) (Solute carrier family 7 member 3)

Accession Number:Q8WY07
Protein Name:Cationic amino acid transporter 3
Length:619
Molecular Weight:67169.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Amino acids

Cross database links:

Genevestigator: Q8WY07
eggNOG: COG0531
HEGENOM: HOG000250623
Entrez Gene ID: 84889   
Drugbank: Drugbank Link   
KEGG: hsa:84889   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015181 F:arginine transmembrane transporter activity
GO:0015326 F:cationic amino acid transmembrane transporter activity
GO:0015189 F:L-lysine transmembrane transporter activity
GO:0000064 F:L-ornithine transmembrane transporter activity
GO:0006865 P:amino acid transport
GO:0006811 P:ion transport
GO:0032006 P:regulation of TOR signaling cascade
GO:0055085 P:transmembrane transport

References (5)

[1] “Human cationic amino acid transporter hCAT-3 is preferentially expressed in peripheral tissues.”  Vekony N.et.al.   11591158
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The DNA sequence of the human X chromosome.”  Ross M.T.et.al.   15772651
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.”  Varela I.et.al.   21248752

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPWQAFRRFG QKLVRRRTLE SGMAETRLAR CLSTLDLVAL GVGSTLGAGV YVLAGEVAKD 
61:	KAGPSIVICF LVAALSSVLA GLCYAEFGAR VPRSGSAYLY SYVTVGELWA FTTGWNLILS 
121:	YVIGTASVAR AWSSAFDNLI GNHISKTLQG SIALHVPHVL AEYPDFFALG LVLLLTGLLA 
181:	LGASESALVT KVFTGVNLLV LGFVMISGFV KGDVHNWKLT EEDYELAMAE LNDTYSLGPL 
241:	GSGGFVPFGF EGILRGAATC FYAFVGFDCI ATTGEEAQNP QRSIPMGIVI SLSVCFLAYF 
301:	AVSSALTLMM PYYQLQPESP LPEAFLYIGW APARYVVAVG SLCALSTSLL GSMFPMPRVI 
361:	YAMAEDGLLF RVLARIHTGT RTPIIATVVS GIIAAFMAFL FKLTDLVDLM SIGTLLAYSL 
421:	VSICVLILRY QPDQETKTGE EVELQEEAIT TESEKLTLWG LFFPLNSIPT PLSGQIVYVC 
481:	SSLLAVLLTA LCLVLAQWSV PLLSGDLLWT AVVVLLLLLI IGIIVVIWRQ PQSSTPLHFK 
541:	VPALPLLPLM SIFVNIYLMM QMTAGTWARF GVWMLIGFAI YFGYGIQHSL EEIKSNQPSR 
601:	KSRAKTVDLD PGTLYVHSV