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2.A.3.3.2
Low affinity basic amino acid transporter (CAT2) (T-cell early activation protein (TEA)) (transports arginine, lysine and ornithine; Na+-independent) (Habermeier et al., 2003)

Accession Number:P18581
Protein Name:CTR2 aka CAT2 aka TEA aka SLC7A2 aka ATRC2
Length:657
Molecular Weight:71866.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Argnine, lysine, Ornithine

Cross database links:

Genevestigator: P18581
eggNOG: roNOG10464
HEGENOM: HBG727793
RefSeq: NP_031540.2   
Entrez Gene ID: 11988   
Pfam: PF00324   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005289 F:high affinity arginine transmembrane transp...
GO:0015189 F:L-lysine transmembrane transporter activity
GO:0000064 F:L-ornithine transmembrane transporter activity
GO:0015809 P:arginine transport
GO:0015807 P:L-amino acid transport
GO:0015819 P:lysine transport
GO:0042116 P:macrophage activation
GO:0006809 P:nitric oxide biosynthetic process
GO:0015822 P:ornithine transport
GO:0002537 P:production of nitric oxide involved in infl...
GO:0050727 P:regulation of inflammatory response
GO:0043030 P:regulation of macrophage activation
GO:0055085 P:transmembrane transport

References (9)

[1] “Activated T cells express a novel gene on chromosome 8 that is closely related to the murine ecotropic retroviral receptor.”  Macleod C.L.et.al.   1694015
[2] “Identification of a low affinity, high capacity transporter of cationic amino acids in mouse liver.”  Closs E.I.et.al.   8385111
[3] “Control of cationic amino acid transport and retroviral receptor functions in a membrane protein family.”  Kavanaugh M.P.et.al.   8195186
[4] “Regulating gene expression through RNA nuclear retention.”  Prasanth K.V.et.al.   16239143
[5] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “Arginine transport via cationic amino acid transporter 2 plays a critical regulatory role in classical or alternative activation of macrophages.”  Yeramian A.et.al.   16670299
[8] “Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry.”  Zanivan S.et.al.   19367708
[9] “The phagosomal proteome in interferon-gamma-activated macrophages.”  Trost M.et.al.   19144319

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MIPCRAVLTF ARCLIRRKIV TLDSLEDSKL CRCLTTVDLI ALGVGSTLGA GVYVLAGEVA 
61:	KADSGPSIVV SFLIAALASV MAGLCYAEFG ARVPKTGSAY LYTYVTVGEL WAFITGWNLI 
121:	LSYVIGTSSV ARAWSGTFDE LLNKQIGQFF KTYFKMNYTG LAEYPDFFAV CLVLLLAGLL 
181:	SFGVKESAWV NKFFTAINIL VLLFVMVAGF VKGNVANWKI SEEFLKNISA SAREPPSENG 
241:	TSIYGAGGFM PYGFTGTLAG AATCFYAFVG FDCIATTGEE VRNPQKAIPI GIVTSLLVCF 
301:	MAYFGVSAAL TLMMPYYLLD EKSPLPVAFE YVRWGPAKYV VAAGSLCALS TSLLGSMFPL 
361:	PRILFAMARD GLLFRFLARV SKRQSPVAAT MTAGVISAVM AFLFDLKALV DMMSIGTLMA 
421:	YSLVAACVLI LRYQPGLCYE QPKYTPEKET LESCTNATLK SESQVTMLQG QGFSLRTLFS 
481:	PSALPTRQSA SLVSFLVGFL AFLILGLSIL TTYGVQAIAR LEAWSLALLA LFLVLCAAVI 
541:	LTIWRQPQNQ QKVAFMVPFL PFLPAFSILV NIYLMVQLSA DTWIRFSIWM ALGFLIYFAY 
601:	GIRHSLEGNP RDEEDDEDAF SENINVATEE KSVMQANDHH QRNLSLPFIL HEKTSEC