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2.A.3.3.9
High affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (Ecotropic retroviral leukemia receptor homologue) (Ecotropic retrovirus receptor homologue) (ERR) (Solute carrier family 7 member 1) (System Y+ basic amino acid transporter) (Closs 1996).

Accession Number:P30825
Protein Name:High affinity cationic amino acid transporter 1
Length:629
Molecular Weight:67638.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Amino acids

Cross database links:

Genevestigator: P30825
eggNOG: COG0531
HEGENOM: HOG000250623
Entrez Gene ID: 6541   
Drugbank: Drugbank Link   
KEGG: hsa:6541   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0015181 F:arginine transmembrane transporter activity
GO:0004872 F:receptor activity
GO:0006865 P:amino acid transport
GO:0006811 P:ion transport
GO:0032006 P:regulation of TOR signaling cascade
GO:0055085 P:transmembrane transport

References (6)

[1] “Molecular cloning and characterization of a novel human gene homologous to the murine ecotropic retroviral receptor.”  Yoshimoto T.et.al.   1718082
[2] “The human cationic amino acid transporter (ATRC1): physical and genetic mapping to 13q12-q14.”  Albritton L.M.et.al.   1348489
[3] “Identification of three cationic amino acid transporters in placental trophoblast: cloning, expression, and characterization of hCAT-1.”  Kamath S.G.et.al.   10485994
[4] “The DNA sequence and analysis of human chromosome 13.”  Dunham A.et.al.   15057823
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.”  Wollscheid B.et.al.   19349973

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGCKVLLNIG QQMLRRKVVD CSREETRLSR CLNTFDLVAL GVGSTLGAGV YVLAGAVARE 
61:	NAGPAIVISF LIAALASVLA GLCYGEFGAR VPKTGSAYLY SYVTVGELWA FITGWNLILS 
121:	YIIGTSSVAR AWSATFDELI GRPIGEFSRT HMTLNAPGVL AENPDIFAVI IILILTGLLT 
181:	LGVKESAMVN KIFTCINVLV LGFIMVSGFV KGSVKNWQLT EEDFGNTSGR LCLNNDTKEG 
241:	KPGVGGFMPF GFSGVLSGAA TCFYAFVGFD CIATTGEEVK NPQKAIPVGI VASLLICFIA 
301:	YFGVSAALTL MMPYFCLDNN SPLPDAFKHV GWEGAKYAVA VGSLCALSAS LLGSMFPMPR 
361:	VIYAMAEDGL LFKFLANVND RTKTPIIATL ASGAVAAVMA FLFDLKDLVD LMSIGTLLAY 
421:	SLVAACVLVL RYQPEQPNLV YQMASTSDEL DPADQNELAS TNDSQLGFLP EAEMFSLKTI 
481:	LSPKNMEPSK ISGLIVNIST SLIAVLIITF CIVTVLGREA LTKGALWAVF LLAGSALLCA 
541:	VVTGVIWRQP ESKTKLSFKV PFLPVLPILS IFVNVYLMMQ LDQGTWVRFA VWMLIGFIIY 
601:	FGYGLWHSEE ASLDADQART PDGNLDQCK