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2.A.3.4.3
γ-aminobutyric acid (GABA) permease, Uga4 (also transports the polyamine, putrescine) (Uemura et al., 2007; Kashiwagi and Igarashi 2011).

Accession Number:P32837
Protein Name:Uga4 aka GABA-specific permease aka GABA-specific transport protein
Length:571
Molecular Weight:61873.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Multi-pass membrane protein2
Substrate Gamma-aminobutyric acid, Putrescine

Cross database links:

Genevestigator: P32837
eggNOG: fuNOG07830
HEGENOM: HBG324420
DIP: DIP-1857N
RefSeq: NP_010071.1   
Entrez Gene ID: 851317   
Pfam: PF00324   
KEGG: sce:YDL210W   

Gene Ontology

GO:0000329 C:fungal-type vacuole membrane
GO:0016021 C:integral to membrane
GO:0015495 F:gamma-aminobutyric acid:hydrogen symporter ...
GO:0015489 F:putrescine transmembrane transporter activity
GO:0015812 P:gamma-aminobutyric acid transport
GO:0015847 P:putrescine transport
GO:0055085 P:transmembrane transport

References (4)

[1] “Cloning and expression of the UGA4 gene coding for the inducible GABA-specific transport protein of Saccharomyces cerevisiae.”  Andre B.et.al.   8455553
[2] “The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.”  Jacq C.et.al.   9169867
[3] “Uptake of GABA and putrescine by UGA4 on the vacuolar membrane in Saccharomyces cerevisiae.”  Uemura T.et.al.   14985124
[4] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSMSSKNENK ISVEQRISTD IGQAYQLQGL GSNLRSIRSK TGAGEVNYID AAKSVNDNQL 
61:	LAEIGYKQEL KRQFSTLQVF GIAFSIMGLL PSIASVMGGG LGGGPATLVW GWFVAAFFIL 
121:	LVGITMAEHA SSIPTAGGLY YWTYYYAPEG YKEIISFIIG CSNSLALAAG VCSIDYGLAE 
181:	EIAAAVTLTK DGNFEVTSGK LYGIFAGAVV VMCICTCVAS GAIARLQTLS IFANLFIIVL 
241:	LFIALPIGTK HRMGGFNDGD FIFGKYENLS DWNNGWQFCL AGFMPAVWTI GSFDSCVHQS 
301:	EEAKDAKKSV PIGIISSIAV CWILGWLIII CLMACINPDI DSVLDSKYGF ALAQIIYDSL 
361:	GKKWAIAFMS LIAFCQFLMG ASITTAVSRQ VWAFSRDNGL PLSKYIKRVD SKYSVPFFAI 
421:	LAACVGSLIL GLLCLIDDAA TDALFSLAVA GNNLAWSTPT VFRLTSGRDL FRPGPFYLGK 
481:	IWSPIVAWTG VAFQLFIIIL VMFPSQQHGI TKSTMNYACV IGPGIWILAG IYYKVYKKKY 
541:	YHGPATNLSD DDYTEAVGAD VIDTIMSKQE P