TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.3.4.4
The 7-keto-8-aminopelargonic acid (KAPA) transporter, Bio5 (Phalip et al., 1999).

Accession Number:P53744
Protein Name:BIO5 aka 7-keto 8-aminopelargonic acid transporter aka KAPA transporter
Length:561
Molecular Weight:62428.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate KAPA

Cross database links:

Genevestigator: P53744
eggNOG: fuNOG14610
HEGENOM: HBG327463
DIP: DIP-7726N
RefSeq: NP_014454.1   
Entrez Gene ID: 855793   
KEGG: sce:YNR056C   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015171 F:amino acid transmembrane transporter activity
GO:0006865 P:amino acid transport
GO:0009102 P:biotin biosynthetic process
GO:0051180 P:vitamin transport

References (3)

[1] “Characterization of the biotin biosynthesis pathway in Saccharomyces cerevisiae and evidence for a cluster containing BIO5, a novel gene involved in vitamer uptake.”  Phalip V.et.al.   10333520
[2] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications.”  Philippsen P.et.al.   9169873
[3] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MNRVGAVFLF VYERNFFLSI VPDRHRTEIR MSSSERSEVK FDKHFNWWSL LGIAFSLSCS 
61:	WVGISASMAV GIASGGPLLI IYGLIIAAFF SLMCGISLGD FAAILPNSSG GSFWVLKMLE 
121:	QESVTLKTPE YEDPSDDDEE VFLENYCQTF NVEVSSKFQK VSSMVVGLLN YFGAIFTTAS 
181:	ICSSLSMSCI GIHKLLHPDY ELKHWHVFVG YECINAVLTL FNIYSTPLPY ISQFGLYTSL 
241:	LSFAMTFIIC IVSRSDNTVD PWPKASNIFG SFDNQTGWNS SGMAFVVGLV NPIWAFVGID 
301:	SATHMIDEVG YSKSRFLVPK VIITTIIVGF VTSFIYCVGL FFCITDQTAV VESILPIVEI 
361:	FYQATGNRNL SVFLQCMCIT TGFVSGIASG TWQSRILQSF GKSYAPFYKE GSLGNKSLKK 
421:	LAVLTPGFKS PLYAHFLSQI CVTIIGCIFM GSSTAFNAII TACITLLLMS YAVPSFIFLF 
481:	VIKKEKFIHR IESDVNCVSR PNRRRMSMIP HIICILWTLF CLVFLSFPYT LPVTAGNMNY 
541:	TSVVYAVVFC IISIVVFPTC I