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2.A.3.4.6
The thiamine (vitamin B1) transporter, Thi9 (SPAC9.10). Uptake is inhibited by pyrithiamine, oxythiamine, amprolium, and the thiazole part of thiamine indicating that these compounds are substrates of Thi9 (Vogl et al., 2008).

Accession Number:Q9UT18
Protein Name:SPAC9.10
Length:591
Molecular Weight:65070.00
Species:Schizosaccharomyces pombe (Fission yeast) [4896]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Thiamine

Cross database links:

eggNOG: fuNOG07714
HEGENOM: HBG324948
RefSeq: NP_593353.1   
Entrez Gene ID: 2543578   
Pfam: PF00324   
KEGG: spo:SPAC9.10   

Gene Ontology

GO:0005783 C:endoplasmic reticulum
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015171 F:amino acid transmembrane transporter activity
GO:0015234 F:thiamin transmembrane transporter activity
GO:0006865 P:amino acid transport
GO:0015888 P:thiamin transport

References (2)

[1] “The genome sequence of Schizosaccharomyces pombe.”  Wood V.et.al.   11859360
[2] “Phosphoproteome analysis of fission yeast.”  Wilson-Grady J.T.et.al.   18257517

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPSSQISHQD PELGQTSSGS SSIKEKAEPQ LYAGPIDPAR RPDVFQEGFE DVSVTDDDND 
61:	NELLRKMGYQ PVLHRSFEFF ESFAASFASL DVVSGVRLTF SWGISFGGPA AYWSAMLVTG 
121:	FCSIVTAACL AEICSALPAA GSIYLWAAES AGPRFGRFVS FLVAWWSTTA WTTFVASITQ 
181:	STANFIFAEV STFNNPWPTN DSDVKFRAVQ WIVAEVLLVF TILLNQVPPR YYKWIFKASM 
241:	LLMFIDYVMN IIWVPVATSK KPDGFRSAKW VFTETIYDQA GYIKEVDDAN GNPIASLSKI 
301:	VPKGWQWCLS YFATAGVIVG YDASGHIAEE TKDASIKAAR GIFYSTVTSF IVAFSLAILY 
361:	LFCCPDLDTF TAILYNDNSP QPFVNFYSYL LGRGGHVVMN VVIILEIFLN GVVSVLACSR 
421:	LVFAVSRDGV LPFSNWISQV SKTGQPKNAI TVIYIVSALL LCTILPSAVA FTSLVSAAGA 
481:	PSFAAYAVLA FCRLFITRDK FPKGRWSLGW LSKPCLVITL VYNLFALVVN VSPYTYPVTG 
541:	PSFNYAVVIM GGVSIFAIIC TIVIPKSRWV ANRYRYESDS EHSASVKELK V