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2.A.3.7.2
The GadC homologue

Accession Number:P75835
Protein Name:Inner membrane transporter ycaM
Length:476
Molecular Weight:52496.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate glutamate, Gamma-aminobutyric acid

Cross database links:

Genevestigator: P75835
EchoBASE: EB3461
EcoGene: EG13697
eggNOG: COG0531
HEGENOM: HBG419260
DIP: DIP-11468N
Entrez Gene ID: 945518   
Pfam: PF00324   
KEGG: ecj:JW5119    eco:b0899   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015171 F:amino acid transmembrane transporter activity
GO:0006865 P:amino acid transport
GO:0055085 P:transmembrane transport

References (4)

[1] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.”  Oshima T.et.al.   8905232
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAGNVQEKQL RWYNIALMSF ITVWGFGNVV NNYANQGLVV VFSWVFIFAL YFTPYALIVG 
61:	QLGSTFKDGK GGVSTWIKHT MGPGLAYLAA WTYWVVHIPY LAQKPQAILI ALGWAMKGDG 
121:	SLIKEYSVVA LQGLTLVLFI FFMWVASRGM KSLKIVGSVA GIAMFVMSLL YVAMAVTAPA 
181:	ITEVHIATTN ITWETFIPHI DFTYITTISM LVFAVGGAEK ISPYVNQTRN PGKEFPKGML 
241:	CLAVMVAVCA ILGSLAMGMM FDSRNIPDDL MTNGQYYAFQ KLGEYYNMGN TLMVIYAIAN 
301:	TLGQVAALVF SIDAPLKVLL GDADSKYIPA SLCRTNASGT PVNGYFLTLV LVAILIMLPT 
361:	LGIGDMNNLY KWLLNLNSVV MPLRYLWVFV AFIAVVRLAQ KYKPEYVFIR NKPLAMTVGI 
421:	WCFAFTAFAC LTGIFPKMEA FTAEWTFQLA LNVATPFVLV GLGLIFPLLA RKANSK