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2.A.3.7.4
Inner membrane transporter, YgjI or GadC. Catalyzes L-glutamate:γ-amino butyrate (GABA) antiport (De Biase and Pennacchietti 2012).

Accession Number:P42590
Protein Name:Inner membrane transporter ygjI
Length:477
Molecular Weight:52147.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Unknown

Cross database links:

Genevestigator: P42590
EchoBASE: EB2579
EcoGene: EG12720
eggNOG: COG0531
HEGENOM: HOG000269875
DIP: DIP-12235N
Entrez Gene ID: 947579   
KEGG: eco:b3078   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015171 F:amino acid transmembrane transporter activity

References (4)

[1] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[2] “Escherichia coli K-12: a cooperatively developed annotation snapshot -- 2005.”  Riley M.et.al.   16397293
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSDTKRNTIG KFGLLSLTFA AVYSFNNVIN NNIELGLASA PMFFLATIFY FIPFCLIIAE 
61:	FVSLNKNSEA GVYAWVKSSL GGRWAFITAY TYWFVNLFFF TSLLPRVIAY ASYAFLGYEY 
121:	IMTPVATTII SMVLFAFSTW VSTNGAKMLG PITSVTSTLM LLLTLSYILL AGTALVGGVQ 
181:	PADAITVDAM IPNFNWAFLG VTTWIFMAAG GAESVAVYVN DVKGGSKSFV KVIILAGIFI 
241:	GVLYSVSSVL INVFVSSKEL KFTGGSVQVF HGMAAYFGLP EALMNRFVGL VSFTAMFGSL 
301:	LMWTATPVKI FFSEIPEGIF GKKTVELNEN GVPARAAWIQ FLIVIPLMII PMLGSNTVQD 
361:	LMNTIINMTA AASMLPPLFI MLAYLNLRAK LDHLPRDFRM GSRRTGIIVV SMLIAIFAVG 
421:	FVASTFPTGA NILTIIFYNV GGIVIFLGFA WWKYSKYIKG LTAEERHIEA TPASNVD