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2.A.3.8.11
The aromatic-preferring amino acid transporter (ArpAT). Functions with rBAT or 4F2hc (8.A.9) and transports preferentially tyr and 3,4-dihydroxyphenylalanine (L-DOPA), but also ala, glu, ser, cys and arg by a Na+-independent mechanism (present in mouse, rat, dog and chicken, but silenced in humans and chimps)(Fernández et al., 2005; Sato et al., 2005)

Accession Number:Q50E62
Protein Name:Aromatic-preferring amino acid transporter
Length:488
Molecular Weight:53100.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Virion membrane1 / Single-pass type III membrane protein2
Substrate tyrosine, tryptophan, phenylalanine, Histadine, Alanine, Glutamic Acid, L-DOPA, Serine, Cystine, Arginine

Cross database links:

Genevestigator: Q50E62
eggNOG: maNOG19025
HEGENOM: HBG714539
RefSeq: NP_001033749.1   
Entrez Gene ID: 328059   
Pfam: PF00324   
KEGG: mmu:328059   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0043234 C:protein complex
GO:0015171 F:amino acid transmembrane transporter activity
GO:0046982 F:protein heterodimerization activity
GO:0006865 P:amino acid transport
GO:0055085 P:transmembrane transport

References (2)

[1] “Identification and functional characterization of a novel low affinity aromatic-preferring amino acid transporter (arpAT). One of the few proteins silenced during primate evolution.”  Fernandez E.et.al.   15757906
[2] “A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.”  Mural R.J.et.al.   12040188

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MERSEEKDGS NKPAGQEQGS GTAGLMLKRE IGLWSAVSMT AGCMIGSGIF MSPQGVLVYI 
61:	GSPGASLIVW ATCGLLAMLG ALCYAELGSL VPESGGDYAY ILRTFGSLPA FLVIYVYVLV 
121:	GRPAGITAVS LSFAEYVLAP FYPGCSSLPQ VIVKIVASSC ILLLLLINFW SSRMSTVLMN 
181:	VCTTAKVFSL LVIVVGGAVV LMQGHASTES LLFAFHNTTQ QAGRIGMAFY QGLWSFDGWS 
241:	NINTVIEELK NPKQNLLWAV MTAVPLVTIL YVLVNISYLL VMSPSEILSS DAIAVIWGDR 
301:	VLGSWAWLVP LAVALSTFGT VNGGFFSGSR VCYAAAREGH MPQLMSMIHV NRLTPAPAQI 
361:	FTTAVALLLV IPGNFSTFVN LLSFLSWLTY GTTFACLLYL RIKTKNLPHT YKVPTFIPAI 
421:	MLLVSLYLVL APIIDHPQIE FLYIFLFVLS GFPVYFLLFH FQCQFKCIQT ATMHLQLLLE 
481:	VAPTTKDH