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2.A.3.8.14
The Asc-type small neutral L-amino acid:H+ symport transporter-2 (Asc-2). Does not associate with 4F2hc or rBAT, but probably associates with some comparable heavy chain. Doesn't transport some substrates of Asc-1 such as α-aminoisobutyric acid and β-alanine (Chairoungdua et al., 2001)

Accession Number:Q8VIE6
Protein Name:Asc-type amino acid transporter 2 aka Asc-2
Length:465
Molecular Weight:50947.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate L-Amino Acids, H+

Cross database links:

Genevestigator: Q8VIE6
RefSeq: NP_543128.1   
Entrez Gene ID: 140918   
Pfam: PF00324   
KEGG: mmu:140918   

Gene Ontology

GO:0005737 C:cytoplasm
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015171 F:amino acid transmembrane transporter activity
GO:0006865 P:amino acid transport
GO:0055085 P:transmembrane transport

References (2)

[1] “Identification and characterization of a novel member of the heterodimeric amino acid transporter family presumed to be associated with an unknown heavy chain.”  Chairoungdua A.et.al.   11591708
[2] “A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.”  Mural R.J.et.al.   12040188

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MQLLRALGVF HVSMILFSAT LGTGIFVTPK AVLKYSSLNI PVSLSIWAGC GLLSIMSALC 
61:	NAEIATTYPL SGASYYFLKR TLGSSVAFLS LWIKLFAHFL GIGAQCLLIA TSVIQCFYSG 
121:	CPAPELPTKC LALAILWSFG IVSARGIKTV AWFNTVSSFI KLSVLCLISL TVLLVNGKKE 
181:	NVSRFENALD AELPNASQIA DAILQVSYSY LGSSVLIVIA GEIKRPTETI PKTLIYGISI 
241:	VTVLYLLTNI SYLAVLTSQE IIFSDSVGVT WMNRVFPSIQ WISSFLISAF LLGSVSCGIV 
301:	SASRVFYSAS QEGEFPSIYS MLNDHHSPAV ADIQIVILSS VAIISSSIIY LVKYVSLGSF 
361:	CINLLQMIGL LKIRYQNPDI PRPYKVWLPF IFGSIALSLF LIFTPVIQSP SIEHVYQVVF 
421:	LFCGFLCYWL QANLNGHATC FDTITCYCQL LFNISPSEDP EEQKN