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2.A.3.8.15
The b0,+ amino acid (cystine) transporter associated with the cystinuria-related type II membrane glycoprotein, BAT1 which forms a heterodimer with rBAT (TC# 8.A.9.1.1). Present in the apical membrane of renal proximal tubules (Chairoungdua et al., 1999)

Accession Number:P82252
Protein Name:B(0,+)-type amino acid transporter 1 aka Bat1
Length:487
Molecular Weight:53658.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Cystine

Cross database links:

Genevestigator: P82252
eggNOG: roNOG12858
RefSeq: NP_446381.1   
Entrez Gene ID: 116726   
Pfam: PF00324   
KEGG: rno:116726   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015175 F:neutral amino acid transmembrane transporte...
GO:0042605 F:peptide antigen binding
GO:0015804 P:neutral amino acid transport
GO:0055085 P:transmembrane transport

References (2)

[1] “Identification of an amino acid transporter associated with the cystinuria-related type II membrane glycoprotein.”  Chairoungdua A.et.al.   10506124
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEETSPRRRR EDEKSVHSTE PKTTSLQKEV GLLSGICIIV GTIIGSGIFI SPKSVLANTE 
61:	SVGPCLIIWA ACGVLATLGA LCFAELGTMI TKSGGEYPYL MEAFGPIPAY LFSWTSLIVM 
121:	KPSSFAIICL SFSEYVCAAF YLGCRPPAVV VKLLAAAAIL LITTVNALSV RLGSYVQNVF 
181:	TAAKLVIVAI IIISGLVLLA QGNVKNFQNS FEGSQTSVGS ISLAFYNGLW AYDGWNQLNY 
241:	ITEELRNPYR NLPMAIVIGI PLVTVCYILM NIAYFTVMTP TELLQSQAVA VTFGDRVLYP 
301:	ASWVVPLFVA FSTIGAANGT CFTAGRLIYV AGREGHMLKV LSYISVKRLT PAPALVFYGI 
361:	IAIIYIIPGD INSLVNYFSF AAWLFYGMTI LGLVVMRFTR KDLERPIKVP IFIPIIVILV 
421:	SVFLILAPII SSPAWEYLYC VLFILSGLIF YFLFVHYKFR WAQKISRPIT KHLQMLMEVV 
481:	PPEKDPE