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2.A.3.8.17
Putative fructoselysine transporter FrlA (Wiame and Van Schaftingen 2004). Also transports psicoselysine. 

Accession Number:P45539
Protein Name:Putative fructoselysine transporter FrlA
Length:445
Molecular Weight:47577.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Fructoselysine, Psicoselysine

Cross database links:

Genevestigator: P45539
EchoBASE: EB2745
EcoGene: EG12908
eggNOG: COG0531
HEGENOM: HOG000005029
DIP: DIP-12322N
Entrez Gene ID: 947878   
KEGG: eco:b3370   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015171 F:amino acid transmembrane transporter activity
GO:0030393 P:fructoselysine metabolic process

References (3)

[1] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[2] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[3] “Identification of a pathway for the utilization of the Amadori product fructoselysine in Escherichia coli.”  Wiame E.et.al.   12147680

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGSQELQRKL GFWAVLAIAV GTTVGSGIFV SVGEVAKAAG TPWLTVLAFV IGGLIVIPQM 
61:	CVYAELSTAY PENGADYVYL KNAGSRPLAF LSGWASFWAN DAPSLSIMAL AIVSNLGFLT 
121:	PIDPLLGKFI AAGLIIAFML LHLRSVEGGA AFQTLITIAK IIPFTIVIGL GIFWFKAENF 
181:	AAPTTTAIGA TGSFMALLAG ISATSWSYTG MASICYMTGE IKNPGKTMPR ALIGSCLLVL 
241:	VLYTLLALVI SGLMPFDKLA NSETPISDAL TWIPALGSTA GIFVAITAMI VILGSLSSCV 
301:	MYQPRLEYAM AKDNLFFKCF GHVHPKYNTP DVSIILQGAL GIFFIFVSDL TSLLGYFTLV 
361:	MCFKNTLTFG SIIWCRKRDD YKPLWRTPAF GLMTTLAIAS SLILVASTFV WAPIPGLICA 
421:	VIVIATGLPA YAFWAKRSRQ LNALS