TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.3.8.19
B(0,+)-type amino acid transporter 1 (B(0,+)AT) (Glycoprotein-associated amino acid transporter b0,+AT1) (Solute carrier family 7 member 9)

Accession Number:P82251
Protein Name:B(0,+)-type amino acid transporter 1
Length:487
Molecular Weight:53481.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Amino acids

Cross database links:

Genevestigator: P82251
eggNOG: COG0531
HEGENOM: HOG000098892
Entrez Gene ID: 11136   
Drugbank: Drugbank Link   
KEGG: hsa:11136   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0015184 F:L-cystine transmembrane transporter activity
GO:0015175 F:neutral amino acid transmembrane transporter activity
GO:0042605 F:peptide antigen binding
GO:0007596 P:blood coagulation
GO:0006520 P:cellular amino acid metabolic process
GO:0006811 P:ion transport
GO:0050900 P:leukocyte migration
GO:0006461 P:protein complex assembly

References (9)

[1] “Non-type I cystinuria caused by mutations in SLC7A9, encoding a subunit (b0,+AT) of rBAT.”  Feliubadalo L.et.al.   10471498
[2] “Luminal heterodimeric amino acid transporter defective in cystinuria.”  Pfeiffer R.et.al.   10588648
[3] “Human cystinuria-related transporter: localization and functional characterization.”  Mizoguchi K.et.al.   11318953
[4] “SLC7A9 mutations in all three cystinuria subtypes.”  Leclerc D.et.al.   12371955
[5] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “Functional analysis of mutations in SLC7A9, and genotype-phenotype correlation in non-type I cystinuria.”  Font M.et.al.   11157794
[8] “Cystinuria in children: distribution and frequencies of mutations in the SLC3A1 and SLC7A9 genes.”  Botzenhart E.et.al.   12234283
[9] “Mutation analysis of SLC7A9 in cystinuria patients in Sweden.”  Harnevik L.et.al.   12820697

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MGDTGLRKRR EDEKSIQSQE PKTTSLQKEL GLISGISIIV GTIIGSGIFV SPKSVLSNTE 
61:	AVGPCLIIWA ACGVLATLGA LCFAELGTMI TKSGGEYPYL MEAYGPIPAY LFSWASLIVI 
121:	KPTSFAIICL SFSEYVCAPF YVGCKPPQIV VKCLAAAAIL FISTVNSLSV RLGSYVQNIF 
181:	TAAKLVIVAI IIISGLVLLA QGNTKNFDNS FEGAQLSVGA ISLAFYNGLW AYDGWNQLNY 
241:	ITEELRNPYR NLPLAIIIGI PLVTACYILM NVSYFTVMTA TELLQSQAVA VTFGDRVLYP 
301:	ASWIVPLFVA FSTIGAANGT CFTAGRLIYV AGREGHMLKV LSYISVRRLT PAPAIIFYGI 
361:	IATIYIIPGD INSLVNYFSF AAWLFYGLTI LGLIVMRFTR KELERPIKVP VVIPVLMTLI 
421:	SVFLVLAPII SKPTWEYLYC VLFILSGLLF YFLFVHYKFG WAQKISKPIT MHLQMLMEVV 
481:	PPEEDPE