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2.A.3.8.22
Y+L amino acid transporter 1 (Monocyte amino acid permease 2) (MOP-2) (Solute carrier family 7 member 7) (y(+)L-type amino acid transporter 1) (Y+LAT1) (y+LAT-1).  It transports cationic amino acids such as arginine and lysine out of the cell. Arginine, in particular, is critical for T-cell activation and function in the immune response, and Y+L   plays a role in the pathogenesis of T-cell acute lymphoblastic leukemia (Ji et al. 2018).

Accession Number:Q9UM01
Protein Name:Y+L amino acid transporter 1
Length:511
Molecular Weight:55991.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Basolateral cell membrane1 / Multi-pass membrane protein2
Substrate Amino acids

Cross database links:

Genevestigator: Q9UM01
eggNOG: COG0531
Entrez Gene ID: 9056   
KEGG: hsa:9056   

Gene Ontology

GO:0016323 C:basolateral plasma membrane
GO:0005887 C:integral to plasma membrane
GO:0015171 F:amino acid transmembrane transporter activity
GO:0006865 P:amino acid transport
GO:0007596 P:blood coagulation
GO:0006520 P:cellular amino acid metabolic process
GO:0006811 P:ion transport
GO:0050900 P:leukocyte migration
GO:0006461 P:protein complex assembly
GO:0055085 P:transmembrane transport

References (20)

[1] “Identification and characterization of a membrane protein (y+L amino acid transporter-1) that associates with 4F2hc to encode the amino acid transport activity y+L. A candidate gene for lysinuric protein intolerance.”  Torrents D.et.al.   9829974
[2] “Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family.”  Pfeiffer R.et.al.   9878049
[3] “SLC7A7, encoding a putative permease-related protein, is mutated in patients with lysinuric protein intolerance.”  Borsani G.et.al.   10080183
[4] “SLC7A7 genomic structure and novel variants in three Japanese lysinuric protein intolerance families.”  Noguchi A.et.al.   10737982
[5] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “Arginine transport through system y(+)L in cultured human fibroblasts: normal phenotype of cells from LPI subjects.”  Dall'Asta V.et.al.   11078698
[8] “Two-way arginine transport in human endothelial cells: TNF-alpha stimulation is restricted to system y(+).”  Sala R.et.al.   11742806
[9] “Nitric oxide synthesis requires activity of the cationic and neutral amino acid transport system y+L in human umbilical vein endothelium.”  Arancibia-Garavilla Y.et.al.   14603368
[10] “INFgamma stimulates arginine transport through system y+L in human monocytes.”  Rotoli B.M.et.al.   15280038
[11] “Activation of classical protein kinase C decreases transport via systems y+ and y+L.”  Rotmann A.et.al.   17329401
[12] “Ornithine transport via cationic amino acid transporter-1 is involved in ornithine cytotoxicity in retinal pigment epithelial cells.”  Kaneko S.et.al.   17197568
[13] “Identification of SLC7A7, encoding y+LAT-1, as the lysinuric protein intolerance gene.”  Torrents D.et.al.   10080182
[14] “Structure of the SLC7A7 gene and mutational analysis of patients affected by lysinuric protein intolerance.”  Sperandeo M.P.et.al.   10631139
[15] “Functional analysis of novel mutations in y+LAT-1 amino acid transporter gene causing lysinuric protein intolerance (LPI).”  Mykkaenen J.et.al.   10655553
[16] “Five novel SLC7A7 variants and y+L gene-expression pattern in cultured lymphoblasts from Japanese patients with lysinuric protein intolerance.”  Shoji Y.et.al.   12402335
[17] “A y(+)LAT-1 mutant protein interferes with y(+)LAT-2 activity: implications for the molecular pathogenesis of lysinuric protein intolerance.”  Sperandeo M.P.et.al.   15756301
[18] “Lysinuric protein intolerance: identification and functional analysis of mutations of the SLC7A7 gene.”  Sperandeo M.P.et.al.   15776427
[19] “The consensus coding sequences of human breast and colorectal cancers.”  Sjoeblom T.et.al.   16959974
[20] “Lysinuric protein intolerance: update and extended mutation analysis of the SLC7A7 gene.”  Sperandeo M.P.et.al.   17764084

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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVDSTEYEVA SQPEVETSPL GDGASPGPEQ VKLKKEISLL NGVCLIVGNM IGSGIFVSPK 
61:	GVLIYSASFG LSLVIWAVGG LFSVFGALCY AELGTTIKKS GASYAYILEA FGGFLAFIRL 
121:	WTSLLIIEPT SQAIIAITFA NYMVQPLFPS CFAPYAASRL LAAACICLLT FINCAYVKWG 
181:	TLVQDIFTYA KVLALIAVIV AGIVRLGQGA STHFENSFEG SSFAVGDIAL ALYSALFSYS 
241:	GWDTLNYVTE EIKNPERNLP LSIGISMPIV TIIYILTNVA YYTVLDMRDI LASDAVAVTF 
301:	ADQIFGIFNW IIPLSVALSC FGGLNASIVA ASRLFFVGSR EGHLPDAICM IHVERFTPVP 
361:	SLLFNGIMAL IYLCVEDIFQ LINYYSFSYW FFVGLSIVGQ LYLRWKEPDR PRPLKLSVFF 
421:	PIVFCLCTIF LVAVPLYSDT INSLIGIAIA LSGLPFYFLI IRVPEHKRPL YLRRIVGSAT 
481:	RYLQVLCMSV AAEMDLEDGG EMPKQRDPKS N