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2.A.3.8.4
L-methionine transporter, MUP1.  Also transports selenomethionine (SeMet) (Kitajima et al. 2010).

Accession Number:P50276
Protein Name:MUP1 aka YGR055W
Length:574
Molecular Weight:63221.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate L-methionine, selenomethionine

Cross database links:

Genevestigator: P50276
eggNOG: fuNOG06296
HEGENOM: HBG448377
DIP: DIP-7914N
RefSeq: NP_011569.1   
Entrez Gene ID: 852946   
Pfam: PF00324   
KEGG: sce:YGR055W   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0042802 F:identical protein binding
GO:0000102 F:L-methionine secondary active transmembrane...
GO:0000101 P:sulfur amino acid transport
GO:0055085 P:transmembrane transport

References (6)

[1] “The study of methionine uptake in Saccharomyces cerevisiae reveals a new family of amino acid permeases.”  Isnard A.D.et.al.   8893857
[2] “Quantitative trait loci mapped to single-nucleotide resolution in yeast.”  Deutschbauer A.M.et.al.   16273108
[3] “The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.”  Tettelin H.et.al.   9169869
[4] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258
[5] “Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.”  Smolka M.B.et.al.   17563356
[6] “A multidimensional chromatography technology for in-depth phosphoproteome analysis.”  Albuquerque C.P.et.al.   18407956

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSEGRTFLSQ LNVFNKENYQ FSSSTTKKEV SNSTVDADNG ASDFEAGQQF ATELDQGEKQ 
61:	LGILSCIGLI CNRMLGTGVF AVSSTIYTLC GSVGLALIMW AVGAIIAISG LYVYMEFGTA 
121:	IPKNGGEKNY LEAIFRKPKF FITCMYAAYI FFLGWAAGNS INTAIMFLTA ADTEVTKWNQ 
181:	RGIGVAVVFF AFLINSLNVK IGLYLQNILG IFKIGIVLFI SITGWVALGG GLKDGYQSHN 
241:	FRNAFEGTET ATAYGIVNAL YSVIWSFVGY SNVNYALGEV KNPVRTLKIA GPTSMVFLAI 
301:	IYIFVNIAYF AVVPKDKLIS SKLILAADFF DIVFGGQAKR AAAALVGLSA LGNVLSVIFS 
361:	QGRIIQQLGR EGVLPFSNFF ASSKPFNSPM VGLFQHFIVC TVTILAPPPG DAYLLVQNLI 
421:	SYPMNIINFA ISAGLLWIYW QRRQGKIEWN PPIKAGVFVT GFFTLSNLYL IIAPYVPPSN 
481:	GESVYSSMPY WIHCVIAWGI FFFGGVYYVV WAQLLPRWGH YKLVSKDVLG EDGFWRVKIA 
541:	KVYDDTIGDV DTQEDGVIET NIIEHYKSEQ EKSL